血浆白细胞介素-18水平及白细胞介素-18基因多态性与丙型肝炎病毒感染结局的关联：一项荟萃分析。
Association of plasma interleukin-18 levels and polymorphisms in interleukin-18 gene with outcomes of hepatitis C virus infections: a meta-analysis.
作者信息
Niu Zhi Li, Zhang Ping An, Tong Yong Qing
机构信息
a Department of Laboratory Science , Renmin Hospital of Wuhan University , Wuhan , China.
出版信息
J Immunoassay Immunochem. 2015;36(3):221-32. doi: 10.1080/15321819.2014.924418.
Several polymorphisms in the interleukin-18 (IL-18) gene and plasma IL-18 levels have been reported to influence hepatitis C virus (HCV) infection. However, the published findings have been conflicting. We conducted meta-analyses of randomized, controlled trials to address the association of IL-18 polymorphisms and plasma IL-18 levels and the outcomes of HCV infection. The results showed that there was no evidence for an association between the HCV infections and the polymorphisms genotypes of IL-18. However, plasma IL-18 levels were found higher in HCV infection patients than in healthy controls. The pooled SMD was 2.911(95% CI 2.556-3.265, z = 16.09, P < 0.001).
据报道，白细胞介素-18（IL-18）基因中的几种多态性以及血浆IL-18水平会影响丙型肝炎病毒（HCV）感染。然而，已发表的研究结果相互矛盾。我们对随机对照试验进行了荟萃分析，以探讨IL-18多态性和血浆IL-18水平与HCV感染结局之间的关联。结果显示，没有证据表明HCV感染与IL-18的多态性基因型之间存在关联。然而，发现HCV感染患者的血浆IL-18水平高于健康对照。合并的标准化均数差为2.911（95%可信区间2.556 - 3.265，z = 16.09，P < 0.001）。
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