遗忘型轻度认知障碍的卡片放置测试及其神经关联

Card-placing test in amnestic mild cognitive impairment and its neural correlates.

作者信息

Lee Seong-Joon, An Young-Sil, Lim Tae Sung, Moon So Young

机构信息

Department of Neurology, School of Medicine, Ajou University, 5 San, Woncheon-dong, Yongtong-gu, Suwon-si, Kyunggi-do 442-749, Republic of Korea.

出版信息

BMC Neurol. 2014 Jun 6;14:123. doi: 10.1186/1471-2377-14-123.

DOI:10.1186/1471-2377-14-123

PMID:24906452

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4058449/

Abstract

BACKGROUND

[corrected] We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI).

METHODS

Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients.

RESULTS

The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus.

CONCLUSIONS

This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.

摘要

背景

[已校正] 我们研究了遗忘型轻度认知障碍（aMCI）患者卡片放置测试（CPT）的解剖学关联。

方法

15名aMCI患者接受了CPT的A部分和B部分以及氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）。使用29名认知正常者的CPT分数和简易精神状态检查表（MMSE）分数进行比较。采用统计参数映射（SPM）相关分析，在对患者的年龄、教育程度和性别进行校正后，提取局部脑代谢变化与CPT的A部分和B部分显著相关的区域。

结果

与正常人群相比，aMCI患者的MMSE分数（26.0 ± 2.0对28.2 ± 1.4，p < 0.001）、CPT A（25.5 ± 3.5对27.7 ± 2.7，p = 0.026）和CPT B分数（16.3 ± 4.4对19.7 ± 3.7，p = 0.011）显著更低。CPT B部分的测试分数与后扣带回和楔前叶的代谢减低密切相关。