PCAF/Hedgehog 轴的阴阳链在癌症控制中的作用。
Yin-Yang strands of PCAF/Hedgehog axis in cancer control.
机构信息
Center for Life Nanoscience (CLNS), Italian Institute of Technology-Sapienza, 00161 Rome, Italy.
Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy.
出版信息
Trends Mol Med. 2014 Aug;20(8):416-8. doi: 10.1016/j.molmed.2014.05.003. Epub 2014 Jun 4.
PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a promising therapeutic target for Hedgehog-dependent tumors.
PCAF（p300/CBP 相关因子）具有乙酰转移酶和最近发现的泛素化活性，可调节基因表达，以响应基因毒性应激或有丝分裂信号。我们强调了 PCAF 在 Hedgehog 信号通路调控中的双重作用，Hedgehog 信号通路是组织发育、干性和肿瘤发生的主要调控因子。通过促进 Hedgehog/GLI1 靶基因启动子处的组蛋白乙酰化，或直接泛素化和 GLI1 的蛋白水解，PCAF/GLI1 轴成为 Hedgehog 依赖性肿瘤的一个有前途的治疗靶点。
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