Körbahti Bahadır K, Taşyürek Selin
Faculty of Engineering, Chemical Engineering Department, University of Mersin, Çiftlikköy, 33343, Mersin, Turkey,
Environ Sci Pollut Res Int. 2015 Mar;22(5):3265-78. doi: 10.1007/s11356-014-3101-7. Epub 2014 Jun 8.
Electrochemical oxidation and process optimization of ampicillin antibiotic at boron-doped diamond electrodes (BDD) were investigated in a batch electrochemical reactor. The influence of operating parameters, such as ampicillin concentration, electrolyte concentration, current density, and reaction temperature, on ampicillin removal, COD removal, and energy consumption was analyzed in order to optimize the electrochemical oxidation process under specified cost-driven constraints using response surface methodology. Quadratic models for the responses satisfied the assumptions of the analysis of variance well according to normal probability, studentized residuals, and outlier t residual plots. Residual plots followed a normal distribution, and outlier t values indicated that the approximations of the fitted models to the quadratic response surfaces were very good. Optimum operating conditions were determined at 618 mg/L ampicillin concentration, 3.6 g/L electrolyte concentration, 13.4 mA/cm(2) current density, and 36 °C reaction temperature. Under response surface optimized conditions, ampicillin removal, COD removal, and energy consumption were obtained as 97.1 %, 92.5 %, and 71.7 kWh/kg CODr, respectively.
在间歇式电化学反应器中研究了硼掺杂金刚石电极（BDD）上氨苄青霉素抗生素的电化学氧化及工艺优化。分析了氨苄青霉素浓度、电解质浓度、电流密度和反应温度等操作参数对氨苄青霉素去除率、化学需氧量（COD）去除率和能耗的影响，以便使用响应面法在特定成本驱动约束下优化电化学氧化工艺。根据正态概率、学生化残差和异常值t残差图，响应的二次模型很好地满足了方差分析的假设。残差图呈正态分布，异常值t值表明拟合模型对二次响应面的近似非常好。确定最佳操作条件为氨苄青霉素浓度618 mg/L、电解质浓度3.6 g/L、电流密度13.4 mA/cm²和反应温度36℃。在响应面优化条件下，氨苄青霉素去除率、COD去除率和能耗分别为97.1%、92.5%和71.7 kWh/kg CODr。
