Jamilloux Y, Sève P, Henry T
Service de médecine interne, CHU de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Centre international de recherche en infectiologie, Inserm U1111, CNRS UMR5308, université Lyon-1, ENS de Lyon, 21, avenue Tony-Garnier, 69365 Lyon, France; Département de biochimie, université de Lausanne, 155, chemin des Boveresses, 1066 Epalinges, Suisse; Université Claude-Bernard - Lyon-1, 69007 Lyon, France.
Service de médecine interne, CHU de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Université Claude-Bernard - Lyon-1, 69007 Lyon, France.
Rev Med Interne. 2014 Nov;35(11):730-41. doi: 10.1016/j.revmed.2014.04.017. Epub 2014 Jun 3.
The understanding of the innate immunity, the first line of the host defence, was significantly modified following the sequential discovery of innate immune receptors such as the Toll-like receptors (TLRs) and the NOD-like receptors (NLRs). In response to recognition of microbial patterns or danger signals, some NLRs assemble a multimolecular platform termed as the inflammasome. Inflammasome assembly leads to the activation of the proinflammatory caspase-1. Consequently, an inflammatory immune response is mounted along with a programmed cell death, called pyroptosis. This review summarizes recent advances in the knowledge of the inflammasome and its role in auto-inflammatory diseases, autoimmune diseases, and most common metabolic, cardiovascular or rheumatic diseases.
随着Toll样受体（TLRs）和NOD样受体（NLRs）等天然免疫受体的相继发现，对作为宿主防御第一道防线的天然免疫的理解有了显著改变。为响应微生物模式或危险信号的识别，一些NLRs组装成一个称为炎性小体的多分子平台。炎性小体的组装导致促炎半胱天冬酶-1的激活。因此，会引发炎症免疫反应以及一种程序性细胞死亡，即细胞焦亡。本综述总结了炎性小体知识及其在自身炎症性疾病、自身免疫性疾病以及最常见的代谢性、心血管或风湿性疾病中的作用的最新进展。
