Yadav Dharmendrasinh Dhansingh, De Tanima, Nagaraja Dindagur, Christopher Rita
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.
Department of Neurology, Dharwad Institute of Mental Health and Neuro Sciences, Dharwad, Karnataka, India.
Clin Appl Thromb Hemost. 2015 Nov;21(8):768-71. doi: 10.1177/1076029614538491. Epub 2014 Jun 6.
Protein Z (PZ), a cofactor for PZ-dependent protease inhibitor, is known to play an important role in inhibiting the coagulation cascade. The aim of the study was to investigate whether PZ G79A polymorphism is a risk factor for puerperal cerebral venous thrombosis (CVT). A total of 71 patients with puerperal CVT and 98 healthy controls were genotyped for PZ 79GA polymorphism by polymerase chain reaction-restriction fragment length polymorphism method. In patients, the genotype distribution for GG, GA, and AA genotypes was 22.5%, 43.7%, and 33.8%, and in controls, 25.5%, 40.8%, and 33.7%, respectively. The risk associated with carrying the mutant genotype (GA and AA) versus the wild GG genotype was found to be 1.11 (95% confidence interval: 0.52-2.35; P = .909). There was no significant difference in the clinical features of the patients with and without the polymorphism. We therefore conclude that PZ G79A polymorphism is not a risk factor for puerperal CVT in Indian women.
蛋白Z（PZ）是依赖于PZ的蛋白酶抑制剂的一种辅因子，已知其在抑制凝血级联反应中发挥重要作用。本研究的目的是探讨PZ G79A多态性是否是产后脑静脉血栓形成（CVT）的危险因素。采用聚合酶链反应-限制性片段长度多态性方法对71例产后CVT患者和98例健康对照者进行PZ 79GA多态性基因分型。患者中，GG、GA和AA基因型的分布分别为22.5%、43.7%和33.8%，对照者中分别为25.5%、40.8%和33.7%。发现携带突变基因型（GA和AA）与野生GG基因型相比的风险为1.11（95%置信区间：0.52-2.35；P = 0.909）。有或无该多态性的患者临床特征无显著差异。因此，我们得出结论，PZ G79A多态性不是印度女性产后CVT的危险因素。
