Alpízar-Rodríguez Deshiré, Romero-Díaz Juanita, Sánchez-Guerrero Jorge, Seuc Armando H, Cravioto María del Carmen
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Division of Rheumatology, Department of Medicine, Mount Sinai Hospital/University Health Network, Toronto, Ontario, Canada, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland and Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Division of Rheumatology, Department of Medicine, Mount Sinai Hospital/University Health Network, Toronto, Ontario, Canada, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland and Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Division of Rheumatology, Department of Medicine, Mount Sinai Hospital/University Health Network, Toronto, Ontario, Canada, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland and Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Rheumatology (Oxford). 2014 Nov;53(11):2023-9. doi: 10.1093/rheumatology/keu222. Epub 2014 Jun 6.
The aim of this study was to estimate the age at natural menopause in women with SLE.
One thousand and thirty-nine consecutive SLE patients <60 years of age were surveyed. Demographic and clinical data were queried by a single investigator. SLE characteristics and co-morbidities were retrieved from their medical records. Natural menopause was defined as amenorrhoea ≥12 months in the absence of previous hysterectomy, CYC exposure and severe chronic kidney disease (SCKD). Pregnant women and those with menses during the 12 months prior to interview were considered premenopausal. Median age at menopause was estimated by both logit and survival analyses. In addition, mean age at menopause was calculated for patients aged ≥40 years. Factors associated with age at natural menopause were assessed by Cox regression analysis.
A total of 961 SLE women were analysed. At interview, most patients (81.6%) were premenopausal, 7.9% had natural menopause, 6.3% were postmenopausal previously exposed to CYC, 4.1% had undergone hysterectomy before menopause and 0.1% presented with SCKD and amenorrhoea. The mean age at interview was 35.2 years (s.d. 10.1), the mean age at SLE diagnosis was 26.9 years (s.d. 8.6) and the mean duration of disease was 8.2 years (s.d. 7.1). The mean recalled age at menopause was 46.4 years (s.d. 4.7). Median age at menopause estimated by logit and survival analyses were 50.7 and 50.8 years, respectively. Only the age at SLE diagnosis was associated with age at natural menopause.
Median age at natural menopause in women with lupus is 50 years. This is consistent with the age at menopause reported in the general population.
本研究旨在评估系统性红斑狼疮（SLE）女性自然绝经的年龄。
对1039例年龄<60岁的连续SLE患者进行调查。由一名研究者询问人口统计学和临床数据。从其病历中获取SLE特征和合并症。自然绝经定义为在未进行过子宫切除术、未接触环磷酰胺（CYC）以及无严重慢性肾病（SCKD）的情况下闭经≥12个月。孕妇以及在访谈前12个月内有月经的女性被视为绝经前。通过logit分析和生存分析估计绝经的中位年龄。此外，计算年龄≥40岁患者的绝经平均年龄。通过Cox回归分析评估与自然绝经年龄相关的因素。
共分析了961例SLE女性。在访谈时，大多数患者（81.6%）处于绝经前，7.9%已自然绝经，6.3%为绝经后且曾接触CYC，4.1%在绝经前接受过子宫切除术，0.1%患有SCKD且闭经。访谈时的平均年龄为35.2岁（标准差10.1），SLE诊断时的平均年龄为26.9岁（标准差8.6），疾病平均病程为8.2年（标准差7.1）。回忆的绝经平均年龄为46.4岁（标准差4.7）。通过logit分析和生存分析估计的绝经中位年龄分别为50.7岁和50.8岁。仅SLE诊断时的年龄与自然绝经年龄相关。
狼疮女性自然绝经的中位年龄为50岁。这与一般人群中报道的绝经年龄一致。
