Fujimori Juichi, Nakashima Ichiro, Kuroda Hiroshi, Fujihara Kazuo, Aoki Masashi
Department of Neurology, Tohoku Pharmaceutical University Hospital, Sendai, Japan.
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
J Neuroimmunol. 2014 Aug 15;273(1-2):77-84. doi: 10.1016/j.jneuroim.2014.05.008. Epub 2014 May 23.
In exceptional cases, patients with aseptic meningitis eventually develop aseptic meningoencephalitis. To find a candidate marker for the development of aseptic meningoencephalitis in adult patients diagnosed with aseptic meningitis, we compared 12 different cytokines/chemokines in cerebrospinal fluid (CSF) from 5 patients with aseptic meningoencephalitis, 8 patients with aseptic meningitis, and 8 patients with control disease. Only the CXCL13 concentration was significantly elevated in the CSF of the group with aseptic meningoencephalitis compared with the group with aseptic meningitis. Thus, CSF CXCL13 may be a useful marker for predicting the prognosis of aseptic meningitis.
在特殊情况下，无菌性脑膜炎患者最终会发展为无菌性脑膜脑炎。为了找到诊断为无菌性脑膜炎的成年患者发生无菌性脑膜脑炎的候选标志物，我们比较了5例无菌性脑膜脑炎患者、8例无菌性脑膜炎患者和8例对照疾病患者脑脊液（CSF）中12种不同的细胞因子/趋化因子。与无菌性脑膜炎组相比，无菌性脑膜脑炎组脑脊液中只有CXCL13浓度显著升高。因此，脑脊液CXCL13可能是预测无菌性脑膜炎预后的有用标志物。
