Franz A P, Rateke L, Hartmann T, McLaughlin N, Torres A R, do Rosário M C, Filho E C M, Ferrão Y A
Federal University of Health Sciences of Porto Alegre, Rua Sarmento Leite, 245, sala 109, Porto Alegre, Rio Grande do Sul, 90050-170 Brazil.
Butler Hospital, Alpert Medical School of Brown University, 45, Prospect Street, Providence, RI, 02912 United States.
Eur Psychiatry. 2015 Jan;30(1):145-51. doi: 10.1016/j.eurpsy.2014.04.007. Epub 2014 Jun 5.
Individuals with obsessive-compulsive disorder (OCD) and separation anxiety disorder (SAD) tend to present higher morbidity than do those with OCD alone. However, the relationship between OCD and SAD has yet to be fully explored.
This was a cross-sectional study using multiple logistic regression to identify differences between OCD patients with SAD (OCD+SAD, n=260) and without SAD (OCD, n=695), in terms of clinical and socio-demographic variables. Data were extracted from those collected between 2005 and 2009 via the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders project.
SAD was currently present in only 42 (4.4%) of the patients, although 260 (27.2%) had a lifetime diagnosis of the disorder. In comparison with the OCD group patients, patients with SAD+OCD showed higher chance to present sensory phenomena, to undergo psychotherapy, and to have more psychiatric comorbidities, mainly bulimia.
In patients with primary OCD, comorbid SAD might be related to greater personal dysfunction and a poorer response to treatment, since sensory phenomena may be a confounding aspect on diagnosis and therapeutics. Patients with OCD+SAD might be more prone to developing specific psychiatric comorbidities, especially bulimia. Our results suggest that SAD symptom assessment should be included in the management and prognostic evaluation of OCD, although the psychobiological role that such symptoms play in OCD merits further investigation.
患有强迫症（OCD）和分离焦虑症（SAD）的个体往往比仅患有强迫症的个体发病率更高。然而，强迫症与分离焦虑症之间的关系尚未得到充分探讨。
这是一项横断面研究，采用多元逻辑回归来确定患有SAD的强迫症患者（OCD+SAD，n=260）和未患有SAD的强迫症患者（OCD，n=695）在临床和社会人口统计学变量方面的差异。数据从2005年至2009年通过巴西强迫症谱系障碍研究联盟项目收集的数据中提取。
目前只有42名（4.4%）患者存在SAD，尽管有260名（27.2%）患者有该疾病的终生诊断。与OCD组患者相比，SAD+OCD患者出现感觉现象、接受心理治疗以及有更多精神共病（主要是贪食症）的可能性更高。
在原发性OCD患者中，共病SAD可能与更大的个人功能障碍和更差的治疗反应有关，因为感觉现象可能是诊断和治疗中的一个混杂因素。OCD+SAD患者可能更容易出现特定的精神共病，尤其是贪食症。我们的结果表明，SAD症状评估应纳入OCD的管理和预后评估中，尽管这些症状在OCD中所起的心理生物学作用值得进一步研究。
