Lacuey Nuria, Zonjy Bilal, Kahriman Emine S, Kaffashi Farhad, Miller Jonathan, Lüders Hans O
Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA,
Brain Struct Funct. 2015 Sep;220(5):2617-23. doi: 10.1007/s00429-014-0810-0. Epub 2014 Jun 8.
The aim of this study is to investigate functional connectivity between right and left mesial temporal structures using cerebrocerebral evoked potentials. We studied seven patients with drug-resistant focal epilepsy who were explored with stereotactically implanted depth electrodes in bilateral hippocampi. In all patients cerebrocerebral evoked potentials evoked by stimulation of the fornix were evaluated as part of a research project assessing fornix stimulation for control of hippocampal seizures. Stimulation of the fornix elicited responses in the ipsilateral hippocampus in all patients with a mean latency of 4.6 ms (range 2-7 ms). Two patients (29 %) also had contralateral hippocampus responses with a mean latency of 7.5 ms (range 5-12 ms) and without involvement of the contralateral temporal neocortex or amygdala. This study confirms the existence of connections between bilateral mesial temporal structures in some patients and explains seizure discharge spreading between homotopic mesial temporal structures without neocortical involvement.
本研究的目的是利用大脑诱发电位研究左右内侧颞叶结构之间的功能连接。我们研究了7例耐药性局灶性癫痫患者，这些患者通过立体定向植入双侧海马深度电极进行探查。作为评估穹窿刺激以控制海马癫痫发作的研究项目的一部分，对所有患者进行了刺激穹窿诱发的大脑诱发电位评估。刺激穹窿在所有患者的同侧海马中均引出反应，平均潜伏期为4.6毫秒（范围为2 - 7毫秒）。2例患者（29%）也有对侧海马反应，平均潜伏期为7.5毫秒（范围为5 - 12毫秒），且对侧颞叶新皮质或杏仁核未受累。本研究证实了部分患者双侧内侧颞叶结构之间存在连接，并解释了癫痫放电在无新皮质受累的情况下在同位内侧颞叶结构之间传播的现象。
