Pichon B, Thillays F, Bourgier C, Mahé M-A, Supiot S
Service de radiothérapie, institut de cancérologie de l'ouest René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France.
Service de radiothérapie, U896, institut régional du cancer de Montpellier, 34298 Montpellier, France.
Cancer Radiother. 2014 Jul-Aug;18(4):342-9. doi: 10.1016/j.canrad.2014.04.005. Epub 2014 Jun 5.
Hypofractionated stereotactic radiotherapy can deliver high doses of bone metastases while sparing adjacent healthy tissue not only for a decompressive or analgesic purpose, but also to improve the local control of the irradiated region. Various phases I or II studies showed the feasibility of such an approach at the cost of limited toxicity, including during re-irradiation. Hypofractionated stereotactic radiotherapy to oligometastases may also improve the long-term control of metastatic disease.
大分割立体定向放射治疗可以在不损伤邻近健康组织的情况下，给予骨转移灶高剂量照射，不仅用于减压或止痛，还能提高照射区域的局部控制率。多项I期或II期研究表明，这种方法是可行的，毒性有限，包括再程照射时。对寡转移灶进行大分割立体定向放射治疗也可能改善转移性疾病的长期控制。
