子宫内膜癌患者卵巢保留的影响。
Impact of ovarian preservation in women with endometrial cancer.
作者信息
Lau Hei-Yu, Twu Nae-Fang, Yen Ming-Shyen, Tsai Hsiao-Wen, Wang Peng-Hui, Chuang Chi-Mou, Wu Hua-Hsi, Chao Kuan-Chong, Chen Yi-Jen
机构信息
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC.
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC.
出版信息
J Chin Med Assoc. 2014 Jul;77(7):379-84. doi: 10.1016/j.jcma.2014.05.002. Epub 2014 Jun 5.
BACKGROUND
Bilateral salpingo-oophorectomy (BSO) is standardly performed in the treatment of endometrial cancer. The purpose of this study was to evaluate the impact of ovarian preservation on the outcome of patients with endometrial cancer.
METHODS
A retrospective cohort study was performed using the 2000-2010 database of endometrial cancer patients who were treated at Taipei Veterans General Hospital. Information regarding patient age, pathologic reports, and follow-up results was abstracted from medical records.
RESULTS
Five hundred and twenty-nine patients were reviewed in this study. Mean age and follow-up duration were 55.7 ± 11.4 years and 37.5 ± 30.1 months, respectively. The median disease-free survival was 31.2 months (range 0.2-126.9 months). There were no significant differences in disease-free survival between stage I patients with ovarian preservation versus those with oophorectomy (p = 0.473). In a multivariate Cox model, ovarian preservation had no effect on disease-free survival [hazard ratio (HR) = 2.72; 95% confidence interval (CI), 0.48-15.59]; however, it was not significantly related to stage and para-aortic lymph node involvement.
CONCLUSION
Ovarian preservation may be considered in premenopausal women with early-stage low-risk endometrial cancer.
背景
双侧输卵管卵巢切除术（BSO）是子宫内膜癌治疗的标准术式。本研究旨在评估保留卵巢对子宫内膜癌患者预后的影响。
方法
利用台北荣民总医院2000 - 2010年子宫内膜癌患者数据库进行回顾性队列研究。从病历中提取患者年龄、病理报告及随访结果等信息。
结果
本研究共纳入529例患者。平均年龄和随访时间分别为55.7±11.4岁和37.5±30.1个月。无病生存期的中位数为31.2个月（范围0.2 - 126.9个月）。I期保留卵巢患者与行卵巢切除术患者的无病生存期无显著差异（p = 0.473）。在多因素Cox模型中，保留卵巢对无病生存期无影响[风险比（HR）= 2.72；95%置信区间（CI），0.48 - 15.59]；然而，它与分期及腹主动脉旁淋巴结受累无显著相关性。
结论
对于早期低风险子宫内膜癌的绝经前女性，可考虑保留卵巢。
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