家畜结核病疫苗接种：TBSTEP项目进展回顾及其对该领域的贡献

Vaccination of domestic animals against tuberculosis: review of progress and contributions to the field of the TBSTEP project.

作者信息

Vordermeier H Martin, Pérez de Val Bernat, Buddle Bryce M, Villarreal-Ramos Bernardo, Jones Gareth J, Hewinson R Glyn, Domingo Mariano

机构信息

Animal Health and Veterinary Laboratories Agency - Wyebridge, Addlestone, Surrey, UK.

Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, Edifici CReSA, Bellaterra, 08193 Catalonia, Spain.

出版信息

Res Vet Sci. 2014 Oct;97 Suppl:S53-60. doi: 10.1016/j.rvsc.2014.04.015. Epub 2014 May 6.

DOI:10.1016/j.rvsc.2014.04.015

PMID:24908189

Abstract

Tuberculosis either caused by Mycobacterium bovis or M. caprae is a significant burden to agricultural industries worldwide. Vaccination of domestic ruminant species such as cattle and goats constitutes a potential tool to support disease control. This review will discuss recent progress made to develop tuberculosis vaccines against domestic ruminants as well as approaches to differentiate vaccinated and infected animals (DIVA) and biomarker discovery studies.

摘要

由牛分枝杆菌或山羊分枝杆菌引起的结核病是全球农业产业的重大负担。对牛和山羊等家养反刍动物进行疫苗接种是支持疾病控制的一种潜在手段。本综述将讨论在开发针对家养反刍动物的结核病疫苗方面取得的最新进展，以及区分接种动物和感染动物的方法（DIVA）和生物标志物发现研究。