Yuan Zhi, Liu Xiaoli, Deng Wentao, Lai Xiaodong, Yan Zaichun, Zheng Ruqiang
Department of Urology, Dongying People's Hospital, No. 317, South First Road, Dongying District, Dongying, 257091, Shandong, China.
Int Urol Nephrol. 2014 Oct;46(10):1871-5. doi: 10.1007/s11255-014-0743-9. Epub 2014 Jun 8.
The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP).
A total of 172 CNBP patients and 151 healthy males were recruited as CNBP and control group, respectively. The prostatic fluid was collected and tested by pre- and post-massage test. White blood cell (WBC) number was counted, and the contents of COX-2 and PGE2 were determined by double antibody-based sandwich enzyme-linked immuno-sorbent assay. The pain and discomfort of each patient were scored according to the National Institutes of Health chronic prostatitis symptom index.
Compared with the control group, CNBP group displayed significantly higher WBC count, COX-2 level, and PGE2 level. Contents of COX-2 and PGE2 in prostatic secretion of CNBP group were positively correlated with pain scores (r = 0.855 and 0.675, respectively, P < 0.01) and total symptom scores (r = 0.674 and 0.566, respectively, P < 0.01). A significantly positive correlation between COX-2 and PGE2 levels was also discovered (r = 0.493, P < 0.05). The WBC number was not obviously correlated with the accumulations of COX-2 and PGE2 or the clinic symptoms of CNBP.
Increase in PGE2 concentration caused by activated COX-2 pathway may contribute to the pain or discomfort symptom of the CNBP patients. Our results indicate that selective COX-2 inhibitors have application prospect in CNBP treatment.
前列腺炎综合征是一种病因多因素且大多未知的病症。本研究旨在分析环氧化酶-2（COX-2）和前列腺素E2（PGE2）与慢性非细菌性前列腺炎（CNBP）之间的关系。
分别招募172例CNBP患者和151例健康男性作为CNBP组和对照组。通过按摩前和按摩后检测收集前列腺液。计数白细胞（WBC）数量，并采用基于双抗体的夹心酶联免疫吸附测定法测定COX-2和PGE2的含量。根据美国国立卫生研究院慢性前列腺炎症状指数对每位患者的疼痛和不适进行评分。
与对照组相比，CNBP组的WBC计数、COX-2水平和PGE2水平显著更高。CNBP组前列腺分泌物中COX-2和PGE2的含量与疼痛评分呈正相关（r分别为0.855和0.675，P<0.01）以及总症状评分呈正相关（r分别为0.674和0.566，P<0.01）。还发现COX-2和PGE2水平之间存在显著正相关（r=0.493，P<0.05）。WBC数量与COX-2和PGE2的积聚或CNBP的临床症状无明显相关性。
COX-2途径激活导致的PGE2浓度升高可能导致CNBP患者出现疼痛或不适症状。我们的结果表明，选择性COX-2抑制剂在CNBP治疗中有应用前景。
