Regmi N, Al-Nahian S
Department of Radiology and Imaging, BIRDEM General Hospital.
Department of General Surgery, BSMMU, Dhaka, Bangladesh.
J Nepal Health Res Counc. 2013 Sep;11(25):296-9.
Adrenocortical carcinoma as a cause of Cushing's syndrome in a child is a rare occurrence. Functioning adrenal carcinomas are detected usually when they are small while non-functioning tumors are incidentally detected when they grow to a large size. Here we report a case of Cushing's syndrome due to large functioning adrenal carcinoma(>12 cm in size) in a 10 year old female child who presented with clinical features of Cushing's syndrome along with virilisation.A combination of biochemical laboratory reports along with radiological investigations followed by histopathology helped us to arrive at a proper diagnosis. The tumor was ressected and the patient showed clinical signs of improvement. However, the surgical margin showed invasion by the tumor making a likely possibility of recurrence in the near future.
肾上腺皮质癌作为儿童库欣综合征的病因较为罕见。功能性肾上腺癌通常在瘤体较小时被发现，而非功能性肿瘤则在生长至较大尺寸时被偶然发现。在此，我们报告一例10岁女童因巨大功能性肾上腺癌（直径>12 cm）导致库欣综合征的病例，该患儿同时伴有男性化的临床表现。结合生化实验室报告、放射学检查及组织病理学检查，我们得以做出准确诊断。肿瘤被切除，患者临床症状有所改善。然而，手术切缘显示有肿瘤侵犯，这使得近期复发的可能性较大。
