Liu Chun-Lian, Jiao Hai-Yan, Ma Qiang, Wu Xing, Jia Shao-Tong, Jing Wan-hong, Yang Qing-Hu
Zhonghua Nan Ke Xue. 2014 May;20(5):419-22.
To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.
Using MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.
The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).
The ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.
探讨DNA修复基因ERCC2单核苷酸多态性（SNP）rs13181、rs1618536和rs1799793对中国宁夏男性特发性不育症的影响。
采用MassArray技术进行病例对照研究，对351例（年龄31.0±4.2岁）特发性不育男性和另外327例正常生育男性（年龄33.0±5.9岁）作为对照进行ERCC2三个SNP rs13181、rs1618536和rs1799793基因分型。
ERCC2 AnyG-anyA-anyA基因型与特发性不育风险增加显著相关（OR 0.414，95%CI 0.176 - 0.970），而ERCC2三个单SNP rs13181、rs1618536和rs1799793在病例组和对照组之间无显著差异（P>0.05）。
ERCC2 SNPs rs13181、rs1618536和rs1799793在宁夏男性特发性不育中起相互作用，增加了患病风险。
