Liu Fei-Fei, Wang Jian-Jun, Shen Qin, Yu Bo, Lu Zhen-Feng, Ma Heng-Hui, Shi Qun-Li
Zhonghua Nan Ke Xue. 2014 May;20(5):435-8.
To investigate the clinicopathological characteristics, diagnosis and treatment of primary testicular yolk sac tumor (YST).
We studied 8 cases of primary testicular YST by microscopy and immunohistochemistry.
The 8 cases of primary testicular YST, including 2 consultation cases, were confirmed from 1998 to 2013, accounting for 10.7% (8/75) of all the testicular germ cell tumors diagnosed in our hospital. The patients ranged in age from 7 to 43 years, 23.9 years on average. The main clinical manifestation of the patients was painless unilateral testis swelling. Microscopically, reticular tissues, schiller-duvaI (S-D) bodies, and eosin-stain transparent bodies were seen in the tumors. One of the cases was confirmed to be simple YST, while the other 7 mixed YST. AFP was a characteristic immunophenotype marker of the tumors.
Primary testicular YST is a rare malignancyr with poor prognosis. Its diagnosis depends on preoperative AFP test and postoperative pathology. Comprehensive treatment, including orchiectomy, chemotherapy, and radiotherapy, can prolong the survival of the patients.
探讨原发性睾丸卵黄囊瘤（YST）的临床病理特征、诊断及治疗方法。
通过显微镜检查和免疫组织化学研究8例原发性睾丸YST。
1998年至2013年确诊8例原发性睾丸YST，包括2例会诊病例，占我院诊断的所有睾丸生殖细胞肿瘤的10.7%（8/75）。患者年龄7至43岁，平均23.9岁。患者的主要临床表现为单侧睾丸无痛性肿大。显微镜下，肿瘤内可见网状组织、席勒-杜瓦尔（S-D）小体和嗜酸性透明小体。其中1例确诊为单纯YST，其余7例为混合性YST。甲胎蛋白（AFP）是肿瘤的特征性免疫表型标志物。
原发性睾丸YST是一种罕见的恶性肿瘤，预后较差。其诊断依赖于术前AFP检测及术后病理检查。综合治疗，包括睾丸切除术、化疗和放疗，可延长患者生存期。
