年龄依赖性药代动力学对催眠药物药效学的影响：两种半衰期不同的催眠药物的比较。
The influence of age-dependent pharmacokinetics on the pharmacodynamics of hypnotic drugs: comparison of two hypnotics with different half-lives.
作者信息
Bergener M, Gola R, Hesse C
机构信息
Rheinische Landesklinik Köln, Federal Republic of Germany.
出版信息
Int Psychogeriatr. 1989 Spring;1(1):17-29. doi: 10.1017/s1041610289000037.
PMID:2490902
Abstract
Drugs with a short elimination half-life should display fewer side effects than longer acting drugs in the treatment of sleep disturbances due to their smaller tendency to accumulate, especially in the elderly. This hypothesis could be confirmed in a double blind study of zopiclone versus flurazepam.
摘要
在治疗睡眠障碍方面，消除半衰期短的药物相较于作用时间长的药物，副作用应更少，因为它们的蓄积倾向较小，在老年人中尤为如此。这一假设在一项佐匹克隆与氟西泮的双盲研究中得到了证实。
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