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右半肝活体肝移植中胆道吻合口狭窄的预防与处理

Prevention and management of biliary anastomotic stricture in right-lobe living-donor liver transplantation.

作者信息

Chok Kenneth S H, Lo Chung Mau

机构信息

Department of Surgery, The University of Hong Kong, Hong Kong, China.

出版信息

J Gastroenterol Hepatol. 2014 Oct;29(10):1756-63. doi: 10.1111/jgh.12648.

Abstract

Biliary strictures can be categorized according to technical factor as anastomotic or nonanastomotic strictures. Biliary anastomotic stricture is a common complication after living-donor liver transplantation, occasionally causing deaths. The two most commonly used methods for biliary anastomosis are duct-to-duct anastomosis and hepaticojejunostomy. Before presenting a description of the latest techniques of duct-to-duct anastomosis and hepaticojejunostomy, this review first relates the technique of donor right hepatectomy, as most biliary complications suffered by recipients of living-donor liver transplantation originate from donor operations. Three possible causes of biliary anastomotic stricture, namely impaired blood supply, biliary anomaly, and technical flaw, are then discussed. Lastly, the review focuses on the latest management of biliary anastomotic stricture. Treatment modalities include endoscopic retrograde cholangiography with dilatation, percutaneous transhepatic biliary drainage with dilatation, conversion of duct-to-duct anastomosis to hepaticojejunostomy, and revision hepaticojejunostomy. End-to-side versus side-to-side hepaticojejunostomy is also discussed.

摘要

胆管狭窄可根据技术因素分为吻合口狭窄或非吻合口狭窄。胆管吻合口狭窄是活体肝移植术后的常见并发症,偶尔会导致死亡。两种最常用的胆管吻合方法是胆管对胆管吻合术和肝空肠吻合术。在介绍胆管对胆管吻合术和肝空肠吻合术的最新技术之前,本综述首先阐述供体右半肝切除术的技术,因为活体肝移植受者的大多数胆管并发症都源于供体手术。然后讨论胆管吻合口狭窄的三个可能原因,即血供受损、胆管异常和技术缺陷。最后,本综述重点关注胆管吻合口狭窄的最新治疗方法。治疗方式包括内镜逆行胆管造影并扩张、经皮经肝胆道引流并扩张、将胆管对胆管吻合术改为肝空肠吻合术以及修复性肝空肠吻合术。还讨论了端侧与侧侧肝空肠吻合术。

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