舞蹈病患者运动皮质兴奋性的变化。
Changes in motor cortical excitability in patients with Sydenham's chorea.
机构信息
Departments of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt.
出版信息
Mov Disord. 2015 Feb;30(2):259-62. doi: 10.1002/mds.25928. Epub 2014 Jun 7.
BACKGROUND AND PURPOSE
The neurophysiological characteristics of motor cortex have been well characterized in patients with Huntington's disease. We present the first data on cortical excitability in patients with Sydenham's chorea.
METHODS
Motor cortex excitability was examined using transcranial magnetic stimulation in 16 patients in the early clinical stages of Sydenham's chorea and in 17 age- and sex-matched control subjects. Investigations included resting and active motor threshold, motor evoked potential, input-output curves, contralateral silent period, and transcallosal inhibition.
RESULTS
Resting and active motor threshold were significantly higher and motor evoked potentials were significantly smaller in patients in comparison with controls. The input-output curves were shallower in both hemispheres of patients with chorea compared with controls. No significant differences were seen in silent period or transcallosal inhibition duration.
CONCLUSION
Sydenham's chorea is characterized by reduced excitability of corticospinal output similar to that observed in Huntington's disease.
背景与目的
亨廷顿病患者的运动皮层神经生理学特征已得到很好的描述。我们首次报道了舞蹈病患者皮质兴奋性的数据。
方法
使用经颅磁刺激对 16 例处于舞蹈病早期临床阶段的患者和 17 名年龄和性别匹配的对照者进行了运动皮层兴奋性检查。检查包括静息和活动运动阈值、运动诱发电位、输入-输出曲线、对侧静息期和皮质间抑制。
结果
与对照组相比，患者的静息和活动运动阈值显著升高，运动诱发电位显著降低。与对照组相比，患者两侧半球的输入-输出曲线均较浅。在静息期或皮质间抑制持续时间方面，未观察到显著差异。
结论
舞蹈病的特征是皮质脊髓输出兴奋性降低，类似于亨廷顿病的表现。
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