Department of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland; Department of Surgery, Satakunta Central Hospital, Pori, Finland.
J Sex Med. 2014 Sep;11(9):2277-84. doi: 10.1111/jsm.12618. Epub 2014 Jun 9.
Erectile dysfunction (ED) is especially common in men with cardiovascular diseases (CVDs). However, the data are scarce concerning populations without manifested CVD.
The aim of this study was to describe factors associated with ED, especially those associated with decreasing risk of ED, in men with cardiovascular risk factors but without CVD, diabetes, or chronic renal disease.
In 2004 to 2007, a cross-sectional population-based sample of men 45 to 70 years old in two rural towns in Finland was collected. Men with previously diagnosed CVD, diabetes, or kidney disease were not invited to the study. In total 1,000 eligible men with cardiovascular risk factors, i.e., central obesity, high scores in the Finnish Diabetes Risk Score, high blood pressure, antihypertensive medication, or family history of coronary heart disease, myocardial infarction, or stroke, were included in the analysis. Questionnaires, clinical measurements, and laboratory tests were obtained. The prevalence of ED was studied comparing the means, and risk factors were studied using multivariate logistic regression analysis.
The rate of ED was defined by the International Index of Erectile Function short form (IIEF-5) and by two questions (2Q) about the ability to achieve and to maintain an erection.
The prevalence of ED was 57% or 68% using IIEF-5 or 2Q, respectively. Age (odds ratio [OR]: up to 9.16; 95% confidence interval [CI], 5.00-16.79; P < 0.001), smoking (OR: 1.41; 95% CI, 1.04-1.91; P = 0.028), depressive symptoms (OR: 4.04 for moderate and severe; 95% CI,1.22-13.45; P = 0.001), high-intensity physical activity (OR: 0.50; 95% CI, 0.29-0.86; P = 0.045), high education (OR: 0.52; 95% CI, 0.33-0.83; P = 0.013), and stable relationship (OR: 0.43; 95% CI, 0.21-0.88; P = 0.046) were associated with ED.
In apparently healthy men with cardiovascular risk factors, decreasing risk of ED is associated with high-intensity physical activity, stable relationship, and high education level.
勃起功能障碍（ED）在患有心血管疾病（CVDs）的男性中尤为常见。然而，对于没有表现出 CVD、糖尿病或慢性肾病的人群，相关数据仍然有限。
本研究旨在描述与 ED 相关的因素，特别是与 ED 风险降低相关的因素，这些因素与患有心血管危险因素但无 CVD、糖尿病或慢性肾病的男性有关。
2004 年至 2007 年，在芬兰的两个农村城镇中收集了年龄在 45 至 70 岁之间的具有心血管危险因素的男性的横断面人群样本。先前诊断为 CVD、糖尿病或肾脏疾病的男性未被邀请参加该研究。总共纳入了 1000 名具有心血管危险因素的合格男性，即中心性肥胖、芬兰糖尿病风险评分高、高血压、抗高血压药物治疗或冠心病、心肌梗死或中风的家族史，分析了这些男性。收集了问卷调查、临床测量和实验室检查结果。通过比较均值来研究 ED 的患病率，并使用多变量逻辑回归分析来研究危险因素。
ED 的发生率通过国际勃起功能指数短表（IIEF-5）和两个关于获得和维持勃起能力的问题（2Q）来定义。
使用 IIEF-5 或 2Q 时，ED 的患病率分别为 57%或 68%。年龄（比值比[OR]：最高 9.16；95%置信区间[CI]，5.00-16.79；P<0.001）、吸烟（OR：1.41；95%CI，1.04-1.91；P=0.028）、抑郁症状（OR：中度和重度为 4.04；95%CI，1.22-13.45；P=0.001）、高强度体力活动（OR：0.50；95%CI，0.29-0.86；P=0.045）、高教育程度（OR：0.52；95%CI，0.33-0.83；P=0.013）和稳定的关系（OR：0.43；95%CI，0.21-0.88；P=0.046）与 ED 相关。
在具有心血管危险因素的看似健康的男性中，ED 风险降低与高强度体力活动、稳定的关系和高教育水平有关。
