Walsh-Messinger Julie, Ramirez Paul Michael, Wong Philip, Antonius Daniel, Aujero Nicole, McMahon Kevin, Opler Lewis A, Malaspina Dolores
Department of Psychology, Long Island University, Brooklyn, NY, United States; InSPIRES, Department of Psychiatry, NYU School of Medicine, New York, NY, United States.
Department of Psychology, Long Island University, Brooklyn, NY, United States.
Schizophr Res. 2014 Aug;157(1-3):63-9. doi: 10.1016/j.schres.2014.05.014. Epub 2014 Jun 6.
Emotion plays a critical role in cognition and goal-directed behavior via complex interconnections between the emotional and motivational systems. It has been hypothesized that the impairment in goal-directed behavior widely noted in schizophrenia may result from defects in the interaction between the neural (ventral) emotional system and (rostral) cortical processes. The present study examined the impact of emotion on attention and memory in schizophrenia. Twenty-five individuals with schizophrenia related psychosis and 25 healthy control subjects were administered a computerized task in which they were asked to search for target images during a Rapid Serial Visual Presentation of pictures. Target stimuli were either positive or negative, or neutral images presented at either 200ms or 700ms lag. Additionally, a visual hedonic task was used to assess differences between the schizophrenia group and controls on ratings of valence and arousal from the picture stimuli. Compared to controls, individuals with schizophrenia detected fewer emotional images under both the 200ms and 700ms lag conditions. Multivariate analyses showed that the schizophrenia group also detected fewer positive images under the 700ms lag condition and fewer negative images under the 200ms lag condition. Individuals with schizophrenia reported higher pleasantness and unpleasantness ratings than controls in response to neutral stimuli, while controls reported higher arousal ratings for neutral and positive stimuli compared to the schizophrenia group. These results highlight dysfunction in the neural modulation of emotion, attention, and cortical processing in schizophrenia, adding to the growing but mixed body of literature on emotion processing in the disorder.
情感通过情感系统和动机系统之间复杂的相互联系，在认知和目标导向行为中发挥着关键作用。据推测，精神分裂症中广泛存在的目标导向行为受损，可能是由于神经（腹侧）情感系统与（嘴侧）皮质过程之间相互作用的缺陷所致。本研究考察了情感对精神分裂症患者注意力和记忆的影响。对25名患有精神分裂症相关精神病的个体和25名健康对照者进行了一项计算机化任务，要求他们在图片快速序列视觉呈现过程中搜索目标图像。目标刺激为正性或负性图像，或延迟200毫秒或700毫秒呈现的中性图像。此外，使用视觉享乐任务来评估精神分裂症组和对照组在图片刺激的效价和唤醒评分上的差异。与对照组相比，精神分裂症患者在200毫秒和700毫秒延迟条件下检测到的情感图像都更少。多变量分析表明，精神分裂症组在700毫秒延迟条件下检测到的正性图像也更少，在200毫秒延迟条件下检测到的负性图像更少。精神分裂症患者对中性刺激的愉悦度和不愉悦度评分高于对照组，而对照组对中性和正性刺激的唤醒评分高于精神分裂症组。这些结果突出了精神分裂症患者在情感、注意力和皮质加工的神经调节方面存在功能障碍，这为该疾病中情感加工方面不断增加但喜忧参半的文献增添了内容。
