肝细胞癌中与RNA结合蛋白相互作用的长链非编码RNA
Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma.
作者信息
Mohamadkhani Ashraf
机构信息
Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
出版信息
Hepat Mon. 2014 May 5;14(5):e18794. doi: 10.5812/hepatmon.18794. eCollection 2014 May.
BACKGROUND
Gene expression microarrays' analyses provide a description of long noncoding RNAs (lncRNAs) with lack of coding protein function that is often important in human cancer.
OBJECTIVES
A number of lncRNAs that have been well characterized in hepatocellular carcinoma (HCC) have been scheduled in this study to discuss for protein-lncRNA interaction.
MATERIALS AND METHODS
The identified lncRNAs were analyzed by bioinformatics tools, starBase and lncRNA db, to anticipate the RNA-binding proteins (RBPs) that tend to interact to HCC-related lncRNAs. The most important predicted RBPs in interaction with well-known lncRNAs in HCC were briefly discussed.
RESULTS
The lncRNAs HOTTIP, H19, HOTAIR, MALAT1, antisense Igf2r (AIR), HOXA13, GTL2 (also called MEG3) and uc002mb have been reported in association with HCC. Besides, this study predicted that eIF4AIII, PTB and FUS were the most involved RBPs in interaction with HCC-related lncRNAs.
CONCLUSIONS
This information provides an explanation for the previously valuable literature on the functions of lncRNAs and suggest for the novel therapeutic targeting.
背景
基因表达微阵列分析提供了对缺乏编码蛋白质功能的长链非编码RNA（lncRNA）的描述，这在人类癌症中通常很重要。
目的
本研究列出了一些在肝细胞癌（HCC）中已得到充分表征的lncRNA，以讨论蛋白质与lncRNA的相互作用。
材料与方法
通过生物信息学工具starBase和lncRNA db对鉴定出的lncRNA进行分析，以预测倾向于与HCC相关lncRNA相互作用的RNA结合蛋白（RBP）。简要讨论了与HCC中著名lncRNA相互作用的最重要预测RBP。
结果
lncRNA HOTTIP、H19、HOTAIR、MALAT1、反义Igf2r（AIR）、HOXA13、GTL2（也称为MEG3）和uc002mb已被报道与HCC有关。此外，本研究预测eIF4AIII、PTB和FUS是与HCC相关lncRNA相互作用中最主要的RBP。
结论
这些信息为先前关于lncRNA功能的有价值文献提供了解释，并为新的治疗靶点提供了建议。
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