Chaudhary Sandeep, Thukral Anubhav, Tiwari Shalbha, Pratyush Daliparthy D, Singh Surya Kumar
Department of Endocrinology, IPGME and R, SSKM Hospital, Kolkata, West Bengal, India.
Institute of Medical sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Indian J Endocrinol Metab. 2013 Dec;17(Suppl 3):S670-3. doi: 10.4103/2230-8210.123564.
Vitamin D deficiency is expected to be higher in patients with diabetes and pulmonary tuberculosis (TB). Studies estimating prevalence in the subset of patients with both diabetes and pulmonary TB are scarce.
A total of 155 subjects were recruited; 46 patients with type 2 diabetes, 39 non-diabetic healthy controls, 30 patients of pulmonary TB and 40 patients with both pulmonary TB and type 2 diabetes. Vitamin D level (25 OH vitamin D) levels were done for all the 4 groups.
Mean vitamin D levels were not different between groups with TB, diabetes mellitus or combination of both, but the prevalence of severe vitamin D deficiency was higher in the group with both diabetes and TB (45%) as compared with the group with only TB (26.66%) and diabetes (17.39%) and healthy controls (7.69%).
The prevalence of patients with severe vitamin D deficiency is higher in patients with dual affection of TB and diabetes mellitus as compared with either disorder alone implying that patients with type 2 diabetes with the most severe vitamin D deficiency are the one of the most predisposed to pulmonary TB.
预计糖尿病和肺结核（TB）患者中维生素D缺乏的情况更为普遍。评估糖尿病合并肺结核患者亚组中维生素D缺乏患病率的研究较少。
共招募了155名受试者；46例2型糖尿病患者、39名非糖尿病健康对照、30例肺结核患者以及40例同时患有肺结核和2型糖尿病的患者。对所有4组进行了维生素D水平（25羟维生素D）检测。
肺结核组、糖尿病组或两者合并组之间的平均维生素D水平无差异，但与仅患肺结核组（26.66%）、糖尿病组（17.39%）和健康对照组（7.69%）相比，糖尿病合并肺结核组中严重维生素D缺乏的患病率更高（45%）。
与单独患有任何一种疾病相比，肺结核和糖尿病双重感染患者中严重维生素D缺乏的患病率更高，这意味着维生素D缺乏最严重的2型糖尿病患者是最易患肺结核的人群之一。
