G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russian Federation.
J Nat Prod. 2014 Jun 27;77(6):1321-8. doi: 10.1021/np500014m. Epub 2014 Jun 9.
Six new highly oxygenated chromene derivatives, oxirapentyns F-K (2-7), one new polyketide (8), one new benzofurane (9), and two known cyclodepsipeptides, isoisariin B and isaridin E, were isolated from the lipophilic extract of the marine-derived fungus Isaria felina KMM 4639. The structures of compounds 2-9 were determined using spectroscopic methods. The relative configurations of compounds 2-7 were established through a combination of NOE data and spin coupling constants, and these results were confirmed by X-ray crystallographic analysis of 4. The absolute structures of all oxirapentyns were assumed based on their biogenetic relationship and confirmed using the modified Mosher's method on 2 and 7. Isariketide (8) showed moderate cytotoxicity toward HL-60 cells.
从海洋来源真菌 Isaria felina KMM 4639 的脂溶性提取物中分离得到了六个新的高度氧化的色烯衍生物，oxirapentyns F-K（2-7），一个新的聚酮（8），一个新的苯并呋喃（9）和两个已知的环二肽，isaritin B 和 isaridin E。化合物 2-9 的结构通过光谱方法确定。通过 NOE 数据和自旋偶合常数的组合确定了化合物 2-7 的相对构型，这些结果通过 4 的 X 射线晶体学分析得到了证实。所有 oxirapentyns 的绝对构型均基于其生物发生关系假设，并通过在 2 和 7 上使用改良的 Mosher 法进行了确认。Isariketide（8）对 HL-60 细胞表现出中等的细胞毒性。
