Clinic for Gynecology, University of Halle, Halle/Saale, Germany.
Clinic for Gynecology, University of Halle, Halle/Saale, Germany.
Semin Cancer Biol. 2015 Apr;31:3-15. doi: 10.1016/j.semcancer.2014.05.006. Epub 2014 Jun 6.
In the last two decades the breast cancer mortality rate has steadily declined, in part, due to the availability of better treatment options. However, drug resistance still remains a major challenge. Resistance can be an inherent feature of breast cancer cells, but can also arise from the tumor microenvironment. This review aims to focus on the modulatory effect of the tumor microenvironment on the differing response of breast cancer subtypes to targeted drugs and chemotherapy.
在过去的二十年中，乳腺癌死亡率稳步下降，部分原因是有了更好的治疗选择。然而，药物耐药性仍然是一个主要挑战。耐药性可能是乳腺癌细胞固有的特征，但也可能源于肿瘤微环境。本文旨在重点探讨肿瘤微环境对不同乳腺癌亚型对靶向药物和化疗反应的调节作用。
