Rosaschino F, Albertini A, Torre R, Noseda F
Ist. di Pediatria dell'Università di Milano.
Boll Ist Sieroter Milan. 1989;68(2):156-66.
In four girls, selected during three years of ambulatory observations, the evolution of repeated upper respiratory tract infection events, under the immunologic aspect, has been studied. The group of girls, with age between 13 and 16 years, practically formed a small casuistry, as an experimental recruitment. With the aim to find the causes of the told infectious events, firstly were checked numerous immune functions, successively were evaluated only the ones that had resulted altered (percentage number of "NK" cells, complement "C3" fraction and "T4" lymphocytes). Particularly significative variations, toward diminution, of the "NK" cells number related to the most compelling school attendance periods were recognized. What observed could let hypothesize that stress and emotions , correlated to scholastic events negatively influence some immune functions, peculiarly the number of "NK" cells. To the lowering of these cells could correspond a facilitation and higher frequency of upper respiratory tract infections (with pharynx as an epicenter), likely by viral aetiology. The subsequent vicarious and/or compensatory intervention by other immune functions could allow, however, the spontaneous recovery, without chemotherapeutic recourse, of the infectious events, that could arise with higher frequency but, most likely, with lower seriousness than could happen when "NK" cells normally act.
在三年的门诊观察中挑选出的四名女孩中，从免疫学角度研究了反复上呼吸道感染事件的发展情况。作为一项实验性招募，这群年龄在13至16岁之间的女孩实际上构成了一个小案例集。为了找出上述感染事件的原因，首先检查了众多免疫功能，随后仅评估那些结果显示异常的免疫功能（“NK”细胞百分比数量、补体“C3”成分和“T4”淋巴细胞）。在与上学最紧张时期相关的时间段内，发现“NK”细胞数量出现了特别显著的减少变化。所观察到的情况可以让人推测，与学业事件相关的压力和情绪会对某些免疫功能产生负面影响，尤其是“NK”细胞的数量。这些细胞数量的减少可能对应着上呼吸道感染（以咽部为中心）的易感性增加和更高的发病频率，可能是由病毒病因引起的。然而，其他免疫功能随后的替代和/或补偿性干预可能会使感染事件在不借助化疗的情况下自然恢复，这些感染事件可能会更频繁地发生，但很可能比“NK”细胞正常发挥作用时的病情严重程度更低。
