De Rienzo B, Borghi V, Cocchi I, Frigeri G, Cavazzuti G B, Pecorari M, Pietrosemoli P, Lami G, Squadrini F
Department of Infectious Diseases; University of Modena.
Boll Ist Sieroter Milan. 1989;68(2):180-4.
Several serological techniques may be used for the detection of HIV infection, however, in the case of infants, there are no methods that are effective prior to the loss of maternal antibodies. Thus, in such cases, a completed series of serological and virological assay of HIV antibodies should be performed in follow-up studies. Twenty children living in Modena (Italy) were studied since 1985. Seven of these children were of ages ranging from 3 to 10 years. Only one of them was found to be seropositive for HIV. The remaining 13 children were studied from birth. Six had lost maternal antibodies to HIV at a median age of 15.1 months. Four showed decreasing levels of the anti-body by Western blotting. HIV antigen was detected in serum samples from 2 children. The data reported stress the need for longitudinal studies that could lead to reliable methods of diagnosing HIV infections in newborns.
有几种血清学技术可用于检测HIV感染，然而，对于婴儿而言，在母体抗体消失之前没有有效的检测方法。因此，在此类情况下，应在后续研究中进行完整系列的HIV抗体血清学和病毒学检测。自1985年以来，对居住在意大利摩德纳的20名儿童进行了研究。其中7名儿童年龄在3至10岁之间。仅发现其中1名儿童HIV血清学呈阳性。其余13名儿童从出生起就开始接受研究。6名儿童在15.1个月的中位年龄时失去了母体HIV抗体。4名儿童通过蛋白质印迹法显示抗体水平下降。在2名儿童的血清样本中检测到HIV抗原。所报告的数据强调了进行纵向研究的必要性，这些研究可能会产生诊断新生儿HIV感染的可靠方法。
