Ersen Ayca, Canda M Serefettin, Men Suleyman, Yucesoy Kemal, Kalemci Orhan, Canda Tulay
Departments of Pathology, Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY.
Turk Patoloji Derg. 2017;33(3):251-255. doi: 10.5146/tjpath.2014.01262.
Angiocentric glioma is an epileptogenic, infiltrative, low grade glial tumor, with ependymal and astrocytic differentiation, most commonly seen in young adults and the pediatric age group. Herein we report a case of 21-year-old male patient who presented with fever and pharmaco-resistant seizures. Computed tomography revealed an iso-dense mass lesion in the gyrus rectus of the left frontal lobe. On magnetic resonance imaging the mass was hyperintense on both T1- and T2-weighted images with no contrast enhancement. Histopathological examination revealed monomorphous tumor cells diffusely infiltrating the neuropil with circumferential, radial, or longitudinal angiocentric alignment and subpial aggregation with perpendicular alignment of the cells to the pial surface. Among central nervous system tumors with ependymal differentiation, this distinct entity is the one with an infiltrating growth pattern. In spite of the infiltrating pattern, it does not seem to have a potential for aggressive behavior.
血管中心性胶质瘤是一种致痫性、浸润性、低级别胶质瘤，具有室管膜和星形细胞分化，最常见于年轻成年人和儿童年龄组。在此，我们报告一例21岁男性患者，其表现为发热和药物难治性癫痫发作。计算机断层扫描显示左额叶直回有等密度肿块病变。磁共振成像显示该肿块在T1加权和T2加权图像上均为高信号，无强化。组织病理学检查显示单形性肿瘤细胞弥漫浸润神经纤维，呈周向、放射状或纵向血管中心排列，细胞在软膜下聚集并与软膜表面垂直排列。在具有室管膜分化的中枢神经系统肿瘤中，这种独特的实体是具有浸润性生长模式的肿瘤。尽管有浸润性模式，但它似乎没有侵袭性行为的潜能。
