肽类抗焦虑药司来吉兰在具有稳定酒精成瘾动机的大鼠戒断综合征模型中的疗效。
Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.
作者信息
Kolik L G, Nadorova A V, Kozlovskaya M M
机构信息
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia,
出版信息
Bull Exp Biol Med. 2014 May;157(1):52-5. doi: 10.1007/s10517-014-2490-4. Epub 2014 Jun 10.
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks. In alcohol-preferring animals (mean daily ethanol intake >5.0 g/kg) allowed free choice between 10 % ethanol and water, single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption. The fi ndings suggest that selank is effective in eliminating of alcohol withdrawal symptoms in rats.
我们研究了硒兰对远交系大鼠急性48小时酒精戒断症状发展的影响，这些大鼠饮用10%乙醇作为唯一液体来源达24周。在偏好酒精的动物（平均每日乙醇摄入量>5.0 g/kg）中，允许它们在10%乙醇和水之间自由选择，单次腹腔注射剂量为0.3 mg/kg的硒兰，在高架十字迷宫试验和社交互动试验中消除了乙醇戒断引起的焦虑，并防止了机械性异常性疼痛的形成，同时不影响乙醇消耗。这些发现表明，硒兰在消除大鼠酒精戒断症状方面是有效的。
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