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肺原发性鳞状细胞癌切除术后结肠转移:一例报告并文献复习

Colonic metastasis after resection of primary squamous cell carcinoma of the lung: a case report and literature review.

作者信息

Lou Hai-Zhou, Wang Chun-Hua, Pan Hong-Ming, Pan Qin, Wang Jin

机构信息

Hai-Zhou Lou, Hong-Ming Pan, Qin Pan, Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China.

出版信息

World J Gastroenterol. 2014 May 21;20(19):5930-4. doi: 10.3748/wjg.v20.i19.5930.

Abstract

Lung cancer is a common malignancy in the world; however symptomatic colonic metastasis from primary lung cancer is rare. A 64-year-old man was originally found poorly differentiated squamous cell carcinoma of right lung and received right lower lobectomy and lymph node dissection. Three years later, the patient presented to our emergency room with the symptom of upper abdominal pain and weight loss. Abdominal palpation and computed tomography scan of the abdomen revealed a large mass measuring 7.6 cm × 8.5 cm in the ascending colon. Colonoscopy and biopsy revealed poorly differentiated squamous cell carcinoma with similar morphological pattern to that of the previous lung cancer. Chemotherapy was given and the patient died 5 mo later. Lung cancer metastatic to the colon confers a poor prognosis: overall survival ranged from 5 wk to 1 year, with a median survival of 3 mo after the diagnosis of the colonic metastasis.

摘要

肺癌是全球常见的恶性肿瘤;然而,原发性肺癌出现有症状的结肠转移却很罕见。一名64岁男性最初被诊断为右肺低分化鳞状细胞癌,并接受了右下肺叶切除术和淋巴结清扫术。三年后,该患者因上腹部疼痛和体重减轻症状就诊于我院急诊室。腹部触诊和腹部计算机断层扫描显示升结肠有一个7.6 cm×8.5 cm的大肿块。结肠镜检查和活检显示为低分化鳞状细胞癌,其形态学模式与先前的肺癌相似。给予化疗,患者5个月后死亡。肺癌转移至结肠预后较差:总体生存期为5周至1年,结肠转移诊断后的中位生存期为3个月。

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