血液系统疾病：艰难梭菌相关性腹泻的高风险
Hematologic diseases: high risk of Clostridium difficile associated diarrhea.
作者信息
Gweon Tae-Geun, Choi Myung-Gyu, Baeg Myong Ki, Lim Chul-Hyun, Park Jae Myung, Lee In Seok, Kim Sang Woo, Lee Dong-Gun, Park Yeon Joon, Lee Jong Wook
机构信息
Tae-Geun Gweon, Myung-Gyu Choi, Myong Ki Baeg, Chul-Hyun Lim, Jae Myung Park, In Seok Lee, Sang Woo Kim, Division of Gastroenterology, Department of Internal Medicine, Seoul St Mary's hospital, The Catholic University of Korea, College of Medicine, Seoul 137-701, South Korea.
出版信息
World J Gastroenterol. 2014 Jun 7;20(21):6602-7. doi: 10.3748/wjg.v20.i21.6602.
AIM
To investigate the incidence and clinical outcome of Clostridium difficile (C. difficile) associated diarrhea (CDAD) in patients with hematologic disease.
METHODS
We retrospectively reviewed the medical records of patients who underwent C. difficile testing in a tertiary hospital in 2011. The incidence and risk factors for CDAD and its clinical course including recurrence and mortality were assessed in patients with hematologic disease and compared with those in patients with nonhematologic disease.
RESULTS
About 320 patients were diagnosed with CDAD (144 patients with hematologic disease; 176 with nonhematologic disease). The incidence of CDAD in patients with hematologic disease was estimated to be 36.7 cases/10000 patient hospital days, which was higher than the 5.4 cases/10000 patient hospital days in patients with nonhematologic disease. Recurrence of CDAD was more frequent in patients with hematologic disease compared to those with nonhematologic disease (18.8% vs 8.5%, P < 0.01), which was associated with higher re-use of causative antibiotics for CDAD. Mortality due to CDAD did not differ between the two groups. Multivariate analysis showed that intravenous immunoglobulin was the only significant factor associated with a lower rate of recurrence of CDAD in patients with hematologic disease.
CONCLUSION
The incidence and recurrence of CDAD was higher in patients with hematologic disease than in those with nonhematologic disease.
目的
调查血液系统疾病患者艰难梭菌相关性腹泻（CDAD）的发病率及临床结局。
方法
我们回顾性分析了2011年在一家三级医院接受艰难梭菌检测的患者的病历。评估血液系统疾病患者中CDAD的发病率、危险因素及其临床病程，包括复发率和死亡率，并与非血液系统疾病患者进行比较。
结果
约320例患者被诊断为CDAD（144例血液系统疾病患者；176例非血液系统疾病患者）。血液系统疾病患者中CDAD的发病率估计为36.7例/10000患者住院日，高于非血液系统疾病患者的5.4例/10000患者住院日。与非血液系统疾病患者相比，血液系统疾病患者中CDAD的复发更频繁（18.8%对8.5%，P<0.01），这与CDAD致病抗生素的再使用率较高有关。两组间CDAD导致的死亡率无差异。多因素分析显示，静脉注射免疫球蛋白是与血液系统疾病患者中CDAD复发率较低相关的唯一显著因素。
结论
血液系统疾病患者中CDAD的发病率和复发率高于非血液系统疾病患者。
Zotero 插件