Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Dev Cell. 2014 Jun 9;29(5):505-506. doi: 10.1016/j.devcel.2014.05.016.
In this issue of Developmental Cell, Fu et al. (2014) address what determines persistent directional movement along microtubules of organelles capable of bidirectional transit. They show that retrograde axonal autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits anterograde movement but may also promote autophagosome maturation.
在本期《发育细胞》中，Fu 等人（2014 年）探讨了是什么决定了能够双向转运的细胞器在微管上持续定向运动。他们表明，逆行轴突自噬体运输是由支架蛋白 JIP1 介导的，JIP1 不仅抑制顺向运动，而且可能促进自噬体成熟。
