Verlinden M
Department of Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium.
Aliment Pharmacol Ther. 1989 Apr;3(2):113-31. doi: 10.1111/j.1365-2036.1989.tb00197.x.
Gastro-oesophageal reflux disease may result from a host of factors. Medical therapy has largely been aimed at neutralizing acid or decreasing acid production but improvement of upper-gastrointestinal motility may prove to be a valuable treatment modality as well. This paper reviews the current state of knowledge of the pathogenesis of reflux disease and concentrates upon promotility treatment with domperidone, metoclopramide and cisapride.
