Müller P, Dammann H G, Leucht U, Simon B
Medizinische Universitätsklinik Heidelberg, Gastroenterologische Abteilung, FRG.
Aliment Pharmacol Ther. 1989 Apr;3(2):193-8. doi: 10.1111/j.1365-2036.1989.tb00205.x.
The effect of increasing doses (15 mg, 30 mg and 60 mg) of the substituted benzimidazole, AG-1749, on gastric acid secretion and fasting serum gastrin concentration has been studied after repeated administration to healthy volunteers. AG-1749 produced a dose-dependent and profound decrease in basal and stimulated gastric acid secretion in all volunteers, with almost total suppression at the highest dose. The extent of inhibition increased between Day 2 and Day 8 with the 15 and 30 mg doses of AG-1749. The inhibitory effect of AG-1749 appears to be fully reversible as control levels of acid output were reached 7 days after drug withdrawal. Seven days' dosing with 60 mg AG-1749 induced a more than threefold increment of fasting serum gastrin concentration, but this increase was still within the normal range. Seven days after cessation of dosing, fasting serum gastrin concentration returned to a pre-dose level.
已对健康志愿者重复给药后，研究了递增剂量（15毫克、30毫克和60毫克）的取代苯并咪唑AG - 1749对胃酸分泌和空腹血清胃泌素浓度的影响。AG - 1749使所有志愿者的基础胃酸分泌和刺激胃酸分泌均出现剂量依赖性的显著降低，在最高剂量时几乎完全抑制。对于15毫克和30毫克剂量的AG - 1749，抑制程度在第2天至第8天有所增加。AG - 1749的抑制作用似乎完全可逆，停药7天后胃酸分泌量达到对照水平。用60毫克AG - 1749给药7天导致空腹血清胃泌素浓度增加超过三倍，但这种增加仍在正常范围内。停药7天后，空腹血清胃泌素浓度恢复到给药前水平。
