Pérez de Oteyza C, Chantres M T, Rebollar J L, Muñoz Yañez M C, García Marcos F, Pérez Barba M, Enríquez de Salamanca R
An Med Interna. 1989 May;6(5):244-8.
The activity of adenosine deaminase was determined in 79 pleural effusions in order to evaluate the utility and reliability in diagnosing tuberculous effusions. The effusions were grouped by the etiology: 26 were tuberculous (group I); 22 were neoplastic (group II); 11 were pneumonic (group III); 10 were non-infections exudates of different causes (group IV); and 10 transudates (group V). Group I presented the higher median value of AD (MED = 81.92; DE: 29.02) the difference being statistically significant (p less than 0.0001) compared with the results of the other groups. We found 2 cases of pleural tuberculosis histologically demonstrated with AD levels under the amount of 40 U/L. In our experience, AD determination had a sensitivity of 92% and specificity of 94%; with a predictive value of 89% and a negative predictive value of 96%, this being considered useful but non specific of tuberculosis.
为评估腺苷脱氨酶在诊断结核性胸腔积液中的实用性和可靠性，对79例胸腔积液进行了腺苷脱氨酶活性测定。根据病因将胸腔积液分组：26例为结核性（第一组）；22例为肿瘤性（第二组）；11例为肺炎性（第三组）；10例为不同病因的非感染性渗出液（第四组）；10例为漏出液（第五组）。第一组腺苷脱氨酶的中位数较高（中位数=81.92；四分位距：29.02），与其他组结果相比，差异具有统计学意义（p<0.0001）。我们发现2例经组织学证实的胸膜结核，其腺苷脱氨酶水平低于40 U/L。根据我们的经验，腺苷脱氨酶测定的敏感性为92%，特异性为94%；阳性预测值为89%，阴性预测值为96%，这被认为对结核病有用但不具有特异性。
