van Eekeren Ramon R J P, Hillebrands Jan Luuk, van der Sloot Kim, de Vries Jean-Paul P M, Zeebregts Clark J, Reijnen Michel M P J
1 Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
J Endovasc Ther. 2014 Jun;21(3):429-33. doi: 10.1583/13-4588MR.1.
To report histological analysis of a great saphenous vein (GSV) 1 year after undergoing mechanochemical endovenous ablation (MOCA) and compare the findings with those of a healthy vein.
A 59-year-old patient with bilateral GSV incompetence was treated with MOCA using the ClariVein catheter, which has a dispersion wire that rotates as liquid sclerosant is injected in the vein. After 1 year, the patient had recurrent edema of the right leg; duplex ultrasound was suspicious for recanalization. The patient was reoperated, and the deep femoral vein was explored. The GSV was completely obliterated, and its proximal part was excised and sent for histological processing. Microscopic evaluation of the MOCA-treated vein showed a circumferential disappearance of the endothelial layer and fibrosis of the vein. The media was considerably damaged, with changes in collagen structure, supporting the therapeutic effect of MOCA.
MOCA is a novel endovenous treatment modality for saphenous vein insufficiency. Results of MOCA on the cellular level are essential to optimize treatment.
报告大隐静脉（GSV）在接受机械化学性静脉腔内消融术（MOCA）1年后的组织学分析结果，并将其与健康静脉的结果进行比较。
一名59岁双侧大隐静脉功能不全的患者接受了使用ClariVein导管的MOCA治疗，该导管有一根分散线，在向静脉内注入液体硬化剂时会旋转。1年后，患者出现右下肢反复水肿；双功超声怀疑有再通。患者再次接受手术，并探查了股深静脉。大隐静脉完全闭塞，其近端部分被切除并送去进行组织学处理。对经MOCA治疗的静脉进行显微镜评估显示，内皮细胞层呈环形消失，静脉出现纤维化。中膜受到相当程度的损伤，胶原结构发生改变，这支持了MOCA的治疗效果。
MOCA是一种用于治疗大隐静脉功能不全的新型静脉腔内治疗方式。MOCA在细胞水平上的结果对于优化治疗至关重要。
