[肺腺癌患者中小窝蛋白-1表达与临床病理特征及预后的相关性]

[Correlation of caveolin-1 expression with clinicopathologic features and prognosis in patients with lung adenocarcinoma].

作者信息

Wang Yanfen, Liu Biao, Xu Yan, Zhang Jin, Xia Qiuyuan, Yu Bo, Zhang Rusong, Shi Shanshan, Lu Zhenfeng, Zhou Xiaojun

机构信息

Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.

Department of Pathology, Jinling Hospital, Nanjing University Medical School; Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China. E-mail:

出版信息

Zhonghua Bing Li Xue Za Zhi. 2014 Apr;43(4):251-5.

PMID:24915816

Abstract

OBJECTIVE

To study the expression, clinicopathologic correlation and prognostic significance of caveolin-1 in lung adenocarcinomas(LAC).

METHODS

Immunohistochemical study (EnVision method) for caveolin-1 and TTF-1 was carried out in 185 cases of LAC encountered during the period from 2005 to 2010. The correlation between caveolin-1 expression and various clinicopathologic parameters was analyzed statistically.

RESULTS

The rate of caveolin-1 expression in the 185 cases of LAC was 26.5% (49/185) and significantly lower than that in normal lung tissue (P<0.01). There was also higher rate of caveolin-1 expression in male patients (P=0.004), smokers (P=0.006), tumors larger than 3.5 cm (P=0.048), predominantly solid tumor subtype (P=0.025), high tumor grade (P=0.044), tumors with vascular invasion (P=0.019), lymph node metastasis (P=0.030), recurrence (P=0.021) and high clinical stage (P=0.027). The expression level of caveolin-1 in TTF1-negative cases was significantly higher than that in TTF1-positive cases and caveolin-1 expression also negatively correlated with TTF-1 expression in LAC (r=-0.154, P=0.037). The five-year overall survival rate of patients with caveolin-1 positive tumors was lower than that in caveolin-1 negative group (P<0.01).Univariate analysis indicated the expression level of caveolin-1 and TTF-1 (P<0.01), histologic subtype (P=0.002), tumor grade (P=0.002), tumor size (P=0.009), vascular invasion (P=0.019), lymph node metastasis (P=0.018), recurrence (P=0.032) and clinical stage (P=0.024) correlated with the survival of patients with LAC. COX multivariate analysis revealed that LAC with caveolin-1 positive expression, TTF-1 negative expression and high tumor grade carried a significantly unfavorable prognosis.

CONCLUSION

Caveolin-1 expression correlates with histologic subtype, tumor grade, invasiveness and metastatic potential of LAC. The detection of caveolin-1 in LAC is helpful in predicting prognosis.LAC with caveolin-1 expression carries a poor prognosis.

摘要

目的

研究小窝蛋白-1在肺腺癌（LAC）中的表达、临床病理相关性及预后意义。

方法

采用免疫组织化学法（EnVision法）检测2005年至2010年期间收治的185例LAC患者的小窝蛋白-1和甲状腺转录因子-1（TTF-1）。对小窝蛋白-1表达与各临床病理参数之间的相关性进行统计学分析。

结果

185例LAC患者中小窝蛋白-1的表达率为26.5%（49/185），显著低于正常肺组织（P<0.01）。男性患者（P=0.004）、吸烟者（P=0.006）、肿瘤直径大于3.5 cm者（P=0.048）、主要为实性肿瘤亚型者（P=0.025）、肿瘤分级高者（P=0.044）、有血管侵犯者（P=0.019）、有淋巴结转移者（P=0.030）、复发者（P=0.021）及临床分期高者（P=0.027）中小窝蛋白-1的表达率也较高。TTF-1阴性病例中小窝蛋白-1的表达水平显著高于TTF-1阳性病例，且LAC中小窝蛋白-1的表达与TTF-1的表达呈负相关（r=-0.154，P=0.037）。小窝蛋白-1阳性肿瘤患者的五年总生存率低于小窝蛋白-1阴性组（P<0.01）。单因素分析表明，小窝蛋白-1和TTF-1的表达水平（P<0.01）、组织学亚型（P=0.002）、肿瘤分级（P=0.002）、肿瘤大小（P=0.009）、血管侵犯（P=0.019）、淋巴结转移（P=0.018）、复发（P=0.032）及临床分期（P=0.024）与LAC患者的生存相关。COX多因素分析显示，小窝蛋白-1阳性表达、TTF-1阴性表达及肿瘤分级高的LAC患者预后明显不良。