蜗牛蛋白和蛞蝓蛋白通过激活表皮生长因子受体-细胞外信号调节激酶介导乳腺癌细胞对他莫昔芬的耐药性，且不依赖于上皮-间质转化。 - Suppr

Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.

作者信息

Jiang Yan, Zhao Xiaotong, Xiao Qian, Liu Qingbo, Ding Keshuo, Yu Fei, Zhang Rui, Zhu Tao, Ge Gaoxiang

机构信息

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Hefei National Laboratory for Physical Sciences, Hefei, Anhui 230027, China.

出版信息

J Mol Cell Biol. 2014 Aug;6(4):352-4. doi: 10.1093/jmcb/mju019. Epub 2014 Jun 10.

DOI:10.1093/jmcb/mju019

PMID:24916398

Abstract

摘要

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Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.蜗牛蛋白和蛞蝓蛋白通过激活表皮生长因子受体-细胞外信号调节激酶介导乳腺癌细胞对他莫昔芬的耐药性，且不依赖于上皮-间质转化。

J Mol Cell Biol. 2014 Aug;6(4):352-4. doi: 10.1093/jmcb/mju019. Epub 2014 Jun 10.

Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells.他莫昔芬耐药乳腺癌细胞中上皮-间质转化表型的获得：G蛋白偶联雌激素受体在通过肿瘤相关成纤维细胞衍生的纤连蛋白和肿瘤细胞中的β1整合素信号通路介导他莫昔芬耐药中的新作用。

Breast Cancer Res. 2015 May 21;17(1):69. doi: 10.1186/s13058-015-0579-y.

IGFBP-1 Expression Promotes Tamoxifen Resistance in Breast Cancer Cells via Erk Pathway Activation.IGFBP-1 通过激活 Erk 通路促进乳腺癌细胞对他莫昔芬的耐药性。

Front Endocrinol (Lausanne). 2020 May 6;11:233. doi: 10.3389/fendo.2020.00233. eCollection 2020.

FGFR signaling maintains a drug persistent cell population following epithelial-mesenchymal transition.成纤维细胞生长因子受体（FGFR）信号传导在上皮-间质转化后维持药物持久性细胞群。

Oncotarget. 2016 Dec 13;7(50):83424-83436. doi: 10.18632/oncotarget.13117.

Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells.雌激素受体介导的他莫昔芬耐药MCF-7细胞中表皮生长因子受体/丝裂原活化蛋白激酶信号通路的调控

Breast Cancer Res Treat. 2003 Sep;81(1):81-93. doi: 10.1023/A:1025484908380.

CXCL5/ENA78 increased cell migration and epithelial-to-mesenchymal transition of hormone-independent prostate cancer by early growth response-1/snail signaling pathway.CXCL5/ENA78 通过早期生长反应因子 1/ sna il 信号通路增加激素非依赖性前列腺癌细胞迁移和上皮间质转化。

J Cell Physiol. 2011 May;226(5):1224-31. doi: 10.1002/jcp.22445.

Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen.雌激素受体的激活功能-1结构域调节他莫昔芬的激动和拮抗作用。

Mol Endocrinol. 2006 May;20(5):996-1008. doi: 10.1210/me.2005-0285. Epub 2006 Feb 2.

Horizontal Transfer of Tamoxifen Resistance in MCF-7 Cell Derivates: Proteome Study.他莫昔芬耐药性在MCF-7细胞衍生物中的横向转移：蛋白质组学研究

Cancer Invest. 2017 Sep 14;35(8):506-518. doi: 10.1080/07357907.2017.1368081.

Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial-to-mesenchymal transition via slug in MCF-7 breast cancer cells.SOX11 的上调通过 slug 增强 MCF-7 乳腺癌细胞对他莫昔芬的耐药性并促进上皮间质转化。

J Cell Physiol. 2020 Oct;235(10):7295-7308. doi: 10.1002/jcp.29629. Epub 2020 Feb 11.

AIB1 is required for the acquisition of epithelial growth factor receptor-mediated tamoxifen resistance in breast cancer cells.乳腺癌细胞中获得表皮生长因子受体介导的他莫昔芬耐药性需要AIB1。

Biochem Biophys Res Commun. 2009 Mar 13;380(3):699-704. doi: 10.1016/j.bbrc.2009.01.155. Epub 2009 Jan 29.

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Prognostic and clinicopathological value of Slug protein expression in breast cancer: a systematic review and meta-analysis.Slug 蛋白表达在乳腺癌中的预后和临床病理价值：系统评价和荟萃分析。

World J Surg Oncol. 2022 Nov 14;20(1):361. doi: 10.1186/s12957-022-02825-6.

Effects of Combined Pentadecanoic Acid and Tamoxifen Treatment on Tamoxifen Resistance in MCF-7/SC Breast Cancer Cells.联合十五烷酸和他莫昔芬治疗对 MCF-7/SC 乳腺癌细胞他莫昔芬耐药的影响。

Int J Mol Sci. 2022 Sep 26;23(19):11340. doi: 10.3390/ijms231911340.

Revisiting Epithelial Carcinogenesis.重新审视上皮性肿瘤发生。

Int J Mol Sci. 2022 Jul 4;23(13):7437. doi: 10.3390/ijms23137437.

Beyond Genetics: Metastasis as an Adaptive Response in Breast Cancer.超越遗传学：乳腺癌转移是一种适应性反应。

Int J Mol Sci. 2022 Jun 3;23(11):6271. doi: 10.3390/ijms23116271.

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.一个机制模型揭示了雌激素受体阳性（ER+）乳腺癌细胞中非遗传异质性和可逆性耐药性的出现及其影响。

NAR Cancer. 2021 Jul 9;3(3):zcab027. doi: 10.1093/narcan/zcab027. eCollection 2021 Sep.

Impact of Selected Signaling Proteins on SNAIL 1 and SNAIL 2 Expression in Ovarian Cancer Cell Lines in Relation to Cells' Cisplatin Resistance and EMT Markers Level.选定信号蛋白对卵巢癌细胞系中 SNAIL1 和 SNAIL2 表达的影响及其与细胞顺铂耐药性和 EMT 标志物水平的关系。

Int J Mol Sci. 2021 Jan 19;22(2):980. doi: 10.3390/ijms22020980.

CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells.CBP 介导的 Slug 乙酰化稳定 Slug 并促进乳腺癌细胞的 EMT 和迁移。

Sci China Life Sci. 2021 Apr;64(4):563-574. doi: 10.1007/s11427-020-1736-5. Epub 2020 Jul 29.

Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells.他莫昔芬再激发可降低人乳腺癌MCF7细胞他莫昔芬介导的细胞毒性抗性亚系的转移潜能，但会增加其细胞活力和克隆形成能力。

Front Cell Dev Biol. 2020 Jun 30;8:485. doi: 10.3389/fcell.2020.00485. eCollection 2020.

Regulation of breast cancer metastasis signaling by miRNAs.miRNAs 调控乳腺癌转移信号通路

Cancer Metastasis Rev. 2020 Sep;39(3):837-886. doi: 10.1007/s10555-020-09905-7.

IGFBP-1 Expression Promotes Tamoxifen Resistance in Breast Cancer Cells via Erk Pathway Activation.IGFBP-1 通过激活 Erk 通路促进乳腺癌细胞对他莫昔芬的耐药性。

Front Endocrinol (Lausanne). 2020 May 6;11:233. doi: 10.3389/fendo.2020.00233. eCollection 2020.

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Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition.

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