Tian Jie, Rui Ke, Wang Shengjun
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Med Hypotheses. 2014 Aug;83(2):151-3. doi: 10.1016/j.mehy.2014.05.006. Epub 2014 May 20.
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play an essential role in tumor-associated immunosuppression, which hampers effective immunotherapeutic approaches. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate target gene expression at the posttranscriptional level. miRNAs are involved in regulating cell proliferation, differentiation and maturation, and abnormal expression and function of miRNAs are recognized in various human diseases. Accumulating evidence shows that various miRNAs modulate the development and differentiation of myeloid cells, which implies their possible role in the differentiation of MDSCs into mature myeloid cells. Our recent studies have found that the classical myeloid differentiation related gene runt-related transcription factor 1 (Runx1) and target nuclear factor 1/A (NFI-A) are modulated during the differentiation and maturation of MDSCs while six miRNAs are found to possibly regulate these two targets by miRNA array analysis. Thus, we hypothesize that the predicted miRNAs may modulate the target genes to regulate the differentiation and maturation of MDSCs. Further studies will provide a novel potential approach for tumor immunotherapy.
髓源性抑制细胞（MDSCs）在荷瘤宿主中积聚，并在肿瘤相关免疫抑制中发挥重要作用，这阻碍了有效的免疫治疗方法。微小RNA（miRNAs）是短的非编码RNA，在转录后水平负向调节靶基因表达。miRNAs参与调节细胞增殖、分化和成熟，并且在各种人类疾病中都发现了miRNAs的异常表达和功能。越来越多的证据表明，各种miRNAs调节髓系细胞的发育和分化，这暗示了它们在MDSCs向成熟髓系细胞分化中可能发挥的作用。我们最近的研究发现，经典的髓系分化相关基因 runt相关转录因子1（Runx1）和靶标核因子1/A（NFI-A）在MDSCs的分化和成熟过程中受到调节，同时通过miRNA阵列分析发现有六种miRNAs可能调节这两个靶标。因此，我们推测预测的miRNAs可能通过调节靶基因来调控MDSCs的分化和成熟。进一步的研究将为肿瘤免疫治疗提供一种新的潜在方法。
