扭转与熨烫：线粒体DNA损伤导致的阿霉素心脏毒性
Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.
作者信息
Nitiss Karin C, Nitiss John L
机构信息
Biomedical Sciences Department, UIC College of Medicine and Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.
出版信息
Clin Cancer Res. 2014 Sep 15;20(18):4737-9. doi: 10.1158/1078-0432.CCR-14-0821. Epub 2014 Jun 10.
Abstract
Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA.
摘要
蒽环类药物是具有多种细胞毒性机制的活性临床药物。蒽环类药物引起的心脏毒性限制了这些药物的治疗潜力，但导致心脏毒性的机制仍存在争议。缺乏线粒体拓扑异构酶I的转基因小鼠对阿霉素心脏毒性高度敏感，这为线粒体DNA损伤引起的心脏毒性提供了支持。
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J Mol Med (Berl). 2014 Aug;92(8):859-69. doi: 10.1007/s00109-014-1147-0. Epub 2014 Apr 13.
2
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3
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Front Pharmacol. 2014 Feb 26;5:25. doi: 10.3389/fphar.2014.00025. eCollection 2014.
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9
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10
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