Franková V
Acta Univ Carol Med (Praha). 1989;35(3-4):167-74.
Mice treated with Cyclophosphamide (Cy) shortly before inoculation of influenza A virus exhibited increased mortality and delayed mean time of death. The extrapulmonary dissemination of the infection was observed more often in Cy-treated animals with the titres of virus in different organs substantially higher than in equally infected immunocompetent controls. Although the humoral antibody response was not impaired in Cy-treated mice, they were more susceptible to challenge with a lethal dose of virus than normal animals. In X-irradiated mice, the increased multiplication of virus in lungs and spread of the infection to other organs was observed, with prolonged persistence of virus in lungs and brains as compared to adequate controls, reminding the author's previous observation in immunocompromised persons, who died in the course of influenza.
在接种甲型流感病毒前不久接受环磷酰胺（Cy）治疗的小鼠死亡率增加，平均死亡时间延迟。在接受Cy治疗的动物中，更常观察到感染的肺外播散，不同器官中的病毒滴度明显高于同样感染的免疫功能正常的对照动物。虽然接受Cy治疗的小鼠体液抗体反应未受损，但与正常动物相比，它们更容易受到致死剂量病毒的攻击。在接受X射线照射的小鼠中，观察到病毒在肺中的增殖增加以及感染扩散到其他器官，与适当的对照相比，病毒在肺和脑中持续存在的时间延长，这使作者想起了之前在免疫功能低下的流感患者身上的观察结果，这些患者在流感病程中死亡。
