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[采用Freestyle无支架生物假体进行主动脉根部置换治疗与主动脉瓣环破坏相关的感染性心内膜炎]

[Aortic root replacement with the freestyle stentless bioprosthesis for infective endocarditis associated with aortic annular destruction].

作者信息

Morishima Yuji, Kugai Tadao, Mabuni Katsuhito, Abe Noriyuki, Yamazato Takahiro

机构信息

Department of Cardiovascular Surgery,Okinawa Prefectural Nanbu Medical Center and Children's Medical Center, Okinawa, Japan.

出版信息

Kyobu Geka. 2014 May;67(5):347-52; discussion 352-5.

Abstract

Treatment of infective endocarditis (IE) associated with aortic annular destruction remains a formidable surgical challenge. Discussions about the optimum modality for reconstruction are still continuing. In such severe endocarditis, we have performed aortic root replacement using the Freestyle stentless bioprosthesis with the full root technique. From 2005 through 2012, 11 patients who had aortic valve endocarditis with annular destruction underwent aortic root replacement at our institute. All of them were treated with the Freestyle stentless bioprosthesis. Their mean age was 69.9 years, and 8 patients were men. Two patients had native valve endocarditis and 9 patients had prosthetic valve endocarditis. Despite appropriate antibiotic therapy, 3 patients required emergency surgery because of hemodynamic deterioration. In-hospital death occurred in 1 patient due to progressive hemodynamic failure. The 10 hospital survivors were followed up for a mean of 27.7±23.1 months (range 5 to 82). Although late death occurred in 2 patients, recurrent IE was not observed in any patients during the follow-up. The results of our study suggest that the Freestyle stentless bioprosthesis could be an excellent alternative to a homograft in the treatment of infective endocarditis associated with aortic annular destruction.

摘要

治疗与主动脉瓣环破坏相关的感染性心内膜炎(IE)仍然是一项艰巨的外科挑战。关于最佳重建方式的讨论仍在继续。在这种严重的心内膜炎中,我们采用全根部技术使用Freestyle无支架生物假体进行主动脉根部置换。从2005年到2012年,11例患有主动脉瓣心内膜炎并伴有瓣环破坏的患者在我们研究所接受了主动脉根部置换。他们均接受了Freestyle无支架生物假体治疗。他们的平均年龄为69.9岁,8例为男性。2例为原发性瓣膜心内膜炎,9例为人工瓣膜心内膜炎。尽管进行了适当的抗生素治疗,但3例患者因血流动力学恶化需要急诊手术。1例患者因进行性血流动力学衰竭在住院期间死亡。10例住院幸存者平均随访27.7±23.1个月(范围5至82个月)。尽管2例患者出现晚期死亡,但随访期间未观察到任何患者发生复发性IE。我们的研究结果表明,在治疗与主动脉瓣环破坏相关的感染性心内膜炎时,Freestyle无支架生物假体可能是同种异体移植物的极佳替代品。

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