生物胶手术粘合剂在尿道下裂修复中的应用。
Use of BioGlue Surgical Adhesive in Hypospadias Repair.
作者信息
Kocherov Stanislav, Lev Genady, Chertin Boris
机构信息
Department of Pediatric Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, Jerusalem, Israel.
出版信息
Curr Urol. 2013 Feb;7(3):132-5. doi: 10.1159/000356265. Epub 2014 Feb 10.
PURPOSE
To prospectively evaluate the efficacy of albumin glutaraldehyde tissue adhesive (BioGlue) in the surgical treatment of patients with hypospadias.
MATERIALS AND METHODS
Two groups of 20 patients each who underwent hypospadias repair were included in the study. In the first group we utilized BioGlue as an additional protective layer to the suture line of the neo-urethra, while patients in the second group were operated on utilizing a routine surgical technique.
RESULTS
There were no statistical differences between patients from the 2 groups in terms of surgical complications. Urethrocutaneous fistula was revealed in 4 (20%) patients after repair with BioGlue and in 3 (15%) patients from the control group (p = 0.686), suture line breakdown in 4 (20%) and in 1 (5%) patients (p = 0.478), meatal stenosis in 1 (5%) and in 1 (5%) patient (p = 1). Furthermore more patients in the BioGlue group (n = 12, 60%) demonstrated poor cosmetic results compared to the control group where most patients - 19 (95%) had acceptable cosmetic outcomes (p = 0.007).
CONCLUSIONS
Our data showed no benefits of BioGlue use in hypospadias repair.
目的
前瞻性评估白蛋白戊二醛组织粘合剂（BioGlue）在尿道下裂患者手术治疗中的疗效。
材料与方法
本研究纳入两组患者，每组20例，均接受尿道下裂修复术。第一组在新尿道缝合线上使用BioGlue作为额外的保护层，而第二组患者采用常规手术技术进行手术。
结果
两组患者在手术并发症方面无统计学差异。使用BioGlue修复后，4例（20%）患者出现尿道皮肤瘘，对照组有3例（15%）患者出现（p = 0.686）；4例（20%）患者出现缝线裂开，对照组有1例（5%）患者出现（p = 0.478）；1例（5%）患者出现尿道口狭窄，对照组有1例（5%）患者出现（p = 1）。此外，与对照组相比，BioGlue组更多患者（n = 12，60%）的美容效果较差，对照组大多数患者 - 19例（95%）的美容效果可接受（p = 0.007）。
结论
我们的数据表明，在尿道下裂修复中使用BioGlue没有益处。
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