Graduate School of Human and Environmental Studies, Kyoto University Kyoto, Japan.
Front Psychol. 2014 Jun 2;5:507. doi: 10.3389/fpsyg.2014.00507. eCollection 2014.
Information on an object's features bound to its location is very important for maintaining object representations in visual working memory. Interactions with dynamic multi-dimensional objects in an external environment require complex cognitive control, including the selective maintenance of feature-location binding. Here, we used event-related functional magnetic resonance imaging to investigate brain activity and functional connectivity related to the maintenance of complex feature-location binding. Participants were required to detect task-relevant changes in feature-location binding between objects defined by color, orientation, and location. We compared a complex binding task requiring complex feature-location binding (color-orientation-location) with a simple binding task in which simple feature-location binding, such as color-location, was task-relevant and the other feature was task-irrelevant. Univariate analyses showed that the dorsolateral prefrontal cortex (DLPFC), hippocampus, and frontoparietal network were activated during the maintenance of complex feature-location binding. Functional connectivity analyses indicated cooperation between the inferior precentral sulcus (infPreCS), DLPFC, and hippocampus during the maintenance of complex feature-location binding. In contrast, the connectivity for the spatial updating of simple feature-location binding determined by reanalyzing the data from Takahama et al. (2010) demonstrated that the superior parietal lobule (SPL) cooperated with the DLPFC and hippocampus. These results suggest that the connectivity for complex feature-location binding does not simply reflect general memory load and that the DLPFC and hippocampus flexibly modulate the dorsal frontoparietal network, depending on the task requirements, with the infPreCS involved in the maintenance of complex feature-location binding and the SPL involved in the spatial updating of simple feature-location binding.
关于对象特征与其位置绑定的信息对于在视觉工作记忆中维持对象表示非常重要。在外部环境中与动态多维对象交互需要复杂的认知控制，包括选择性地保持特征-位置绑定。在这里，我们使用事件相关功能磁共振成像来研究与维持复杂特征-位置绑定相关的大脑活动和功能连接。参与者需要检测对象的特征-位置绑定之间的任务相关变化，这些对象由颜色、方向和位置定义。我们将需要复杂特征-位置绑定（颜色-方向-位置）的复杂绑定任务与简单绑定任务进行了比较，在简单绑定任务中，颜色-位置等简单特征-位置绑定是任务相关的，而其他特征是任务无关的。单变量分析表明，背外侧前额叶皮层（DLPFC）、海马体和额顶网络在维持复杂特征-位置绑定时被激活。功能连接分析表明，在维持复杂特征-位置绑定期间，下前中央沟（infPreCS）、DLPFC 和海马体之间存在合作。相比之下，通过重新分析 Takahama 等人的数据（2010 年）来确定简单特征-位置绑定的空间更新的连通性表明，上顶叶皮层（SPL）与 DLPFC 和海马体合作。这些结果表明，复杂特征-位置绑定的连通性并不简单地反映一般记忆负载，并且 DLPFC 和海马体根据任务要求灵活地调节背侧额顶网络，infPreCS 参与复杂特征-位置绑定的维持，而 SPL 参与简单特征-位置绑定的空间更新。
