Jedynak Waldemar, Cieszanowski Andrzej
Department of Diagnostic Imaging, Hospital of the West, Jan Paul II, Grodzisk Mazowiecki, Poland.
2 Department of Radiology, Laboratory of Magnetic Resonance, Medical University of Warsaw, Warsaw, Poland.
Pol J Radiol. 2014 Jun 2;79:131-6. doi: 10.12659/PJR.890379. eCollection 2014.
Summary Though the etiology of multiple sclerosis remains unknown, the widely accepted explanation is that it has an autoimmune inflammatory background. In 2006 Paolo Zamboni renewed the somewhat forgotten vascular theory of the pathogenesis of multiple sclerosis, proposing the new entity of 'chronic cerebrospinal venous insufficiency'. As a result of this hypothesis, Zamboni suggested an endovascular treatment for multiple sclerosis involving venoplasty of the internal jugular vein and the azygos vein. Unfortunately, several teams have tried to replicate Zamboni's results without success. In this review, we present a chronological description of the results of the studies conducted by Zamboni and the later attempts to replicate his work. The main conclusion is that, taking into account results that are currently available, we should remain cautious and routine use of this treatment in patients should not be advisable.
摘要 尽管多发性硬化症的病因尚不清楚，但被广泛接受的解释是它具有自身免疫性炎症背景。2006年，保罗·赞博尼重新提出了某种程度上被遗忘的多发性硬化症发病机制的血管理论，提出了“慢性脑脊髓静脉功能不全”这一新概念。基于这一假说，赞博尼建议对多发性硬化症采用血管内治疗，包括颈内静脉和奇静脉的血管成形术。不幸的是，几个研究团队试图重现赞博尼的结果，但均未成功。在本综述中，我们按时间顺序描述了赞博尼所开展研究的结果以及后来试图重现其研究成果的情况。主要结论是，考虑到目前可得的结果，我们应保持谨慎，不建议在患者中常规使用这种治疗方法。
