粪便生物标志物在克罗恩病诊断和监测中的应用
Fecal biomarkers in the diagnosis and monitoring of Crohn's disease.
作者信息
Wright Emily K, De Cruz Peter, Gearry Richard, Day Andrew S, Kamm Michael A
机构信息
*St. Vincent's Hospital and University of Melbourne, Melbourne, Australia; and †Christchurch Hospital and University of Otago, Christchurch, New Zealand.
出版信息
Inflamm Bowel Dis. 2014 Sep;20(9):1668-77. doi: 10.1097/MIB.0000000000000087.
The diagnosis and monitoring of Crohn's disease has traditionally relied on clinical assessment, serum markers of inflammation, and endoscopic examination. Fecal biomarkers such as calprotectin, lactoferrin, and S100A12 are predominantly derived from neutrophils, are easily detectable in the feces, and are emerging as valuable markers of intestinal inflammation. This review focuses on the role of fecal biomarkers in the diagnosis and monitoring of Crohn's disease, in particular how these biomarkers change with disease activity and remission, how they can be used to monitor the response to medical therapy, their value in predicting clinical relapse, and their role in monitoring the postoperative state.
克罗恩病的诊断和监测传统上依赖于临床评估、炎症血清标志物和内镜检查。粪便生物标志物，如钙卫蛋白、乳铁蛋白和S100A12，主要来源于中性粒细胞，在粪便中易于检测，并且正逐渐成为肠道炎症的重要标志物。本综述重点关注粪便生物标志物在克罗恩病诊断和监测中的作用，特别是这些生物标志物如何随疾病活动和缓解而变化，它们如何用于监测药物治疗反应、预测临床复发的价值以及在监测术后状态中的作用。
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