坏死性小肠结肠炎期间粪便钙卫蛋白水平升高与活化的中性粒细胞释放中性粒细胞胞外诱捕网有关。
Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps.
作者信息
MacQueen B C, Christensen R D, Yost C C, Lambert D K, Baer V L, Sheffield M J, Gordon P V, Cody M J, Gerday E, Schlaberg R, Lowe J, Shepherd J G
机构信息
Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Women and Newborn's Clinical Program, Intermountain Healthcare, Salt Lake City, UT, USA.
出版信息
J Perinatol. 2016 Oct;36(10):862-9. doi: 10.1038/jp.2016.105. Epub 2016 Jul 7.
OBJECTIVE
Neonates with necrotizing enterocolitis (NEC) have higher calprotectin levels in stool than do healthy neonates. However, it is not known whether high stool calprotectin at the onset of bowel symptoms identifies neonates who truly have NEC vs other bowel disorders.
STUDY DESIGN
Neonates were eligible for this study when an x-ray was ordered to 'rule-out NEC'. Stool calprotectin was quantified at that time and in a follow-up stool. Each episode was later categorized as NEC or not NEC. The location of calprotectin in the bowel was determined by immunohistochemistry.
RESULTS
Neonates with NEC had higher initial and follow-up stool calprotectin levels than did neonates without NEC. Calprotectin in bowel from neonates with NEC was within neutrophil extracellular traps (NETs).
CONCLUSION
At the onset of signs concerning for NEC, fecal calprotectin is likely to be higher in neonates with NEC. Calprotectin in their stools is exported from neutrophils via NETs.
目的
坏死性小肠结肠炎（NEC）新生儿的粪便钙卫蛋白水平高于健康新生儿。然而，在肠道症状出现时，粪便钙卫蛋白水平升高是否能鉴别出真正患有NEC的新生儿与其他肠道疾病尚不清楚。
研究设计
当因“排除NEC”而进行X光检查时，新生儿符合本研究条件。此时对粪便钙卫蛋白进行定量，并在后续粪便中再次定量。每例病例随后被分类为NEC或非NEC。通过免疫组织化学确定钙卫蛋白在肠道中的位置。
结果
患有NEC的新生儿其初始和后续粪便钙卫蛋白水平高于未患NEC的新生儿。患有NEC的新生儿肠道中的钙卫蛋白存在于中性粒细胞胞外诱捕网（NETs）内。
结论
在出现NEC相关体征时，患有NEC的新生儿粪便钙卫蛋白水平可能更高。他们粪便中的钙卫蛋白是通过NETs从中性粒细胞排出的。
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