Almueilo Samir H, Alsulaiman Raed M
From King Fahd Hospital, University of Dammam, Al Khobar, Saudi Arabia.
Exp Clin Transplant. 2015 Apr;13(2):196-9. doi: 10.6002/ect.2013.0264. Epub 2014 Jun 9.
Mycophenolate mofetil is a component of immunosuppressive regimens in solid-organ transplant recipients. Gastrointestinal symptoms such as nausea, abdominal pain, and diarrhea without fever are common in patients treated with mycophenolate mofetil. We treated a patient who had acute colonic pseudo-obstruction after kidney transplant that resolved after discontinuing mycophenolate mofetil. The disorder recurred soon after resuming mycophenolate mofetil, which is evidence for an association between mycophenolate mofetil and acute colonic pseudo-obstruction in this patient.
霉酚酸酯是实体器官移植受者免疫抑制方案的一个组成部分。接受霉酚酸酯治疗的患者常见恶心、腹痛和腹泻等无发热的胃肠道症状。我们治疗了一名肾移植后发生急性结肠假性梗阻的患者，停用霉酚酸酯后病情缓解。重新使用霉酚酸酯后不久该病症复发，这证明在该患者中霉酚酸酯与急性结肠假性梗阻之间存在关联。
