Lei Zhiwei, Wang Jie, Mao Genlin, Wen Yingjie, Tian Yuxin, Wu Huawei, Li Yufeng, Xu Hanhong
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, and Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University , Guangzhou, Guangdong 510642, People's Republic of China.
J Agric Food Chem. 2014 Jul 2;62(26):6065-71. doi: 10.1021/jf5010429. Epub 2014 Jun 19.
In our previous work, a glucose-fipronil (GTF) conjugate at the C-1 position was synthesized via click chemistry and a glucose moiety converted a non-phloem-mobile insecticide fipronil into a moderately phloem-mobile insecticide. In the present paper, fipronil was introduced into the C-2, C-3, C-4, and C-6 positions of glucose via click chemistry to obtain four new conjugates and to evaluate the effects of the different glucose isomers on phloem mobility. The phloem mobility of the four new synthetic conjugates and GTF was tested using the Ricinus seedling system. The results confirmed that conjugation of glucose at different positions has a significant influence on the phloem mobility of GTF conjugates.
在我们之前的工作中，通过点击化学在C-1位合成了葡萄糖-氟虫腈（GTF）缀合物，葡萄糖部分将一种非韧皮部移动性杀虫剂氟虫腈转化为一种中等韧皮部移动性杀虫剂。在本文中，通过点击化学将氟虫腈引入葡萄糖的C-2、C-3、C-4和C-6位，以获得四种新的缀合物，并评估不同葡萄糖异构体对韧皮部移动性的影响。使用蓖麻幼苗系统测试了四种新合成缀合物和GTF的韧皮部移动性。结果证实，在不同位置连接葡萄糖对GTF缀合物的韧皮部移动性有显著影响。
